**11. The prevalence of abortion in PCO is probably elevated**


Usually, women with PCOS require different treatments due to variety of reasons so we can use metformin, diet and infertility drugs. Therapeutic management combines normalization of weight and administration of metformin to reduce mainly the RPL rate [60–68].

### **12. Infections**

Any infection with high fever can lead to miscarriage rubella virus, cytomegalovirus passing the placenta and affecting the fetus, malaria, mycoplasma, and trypanosomiasis.

Several studies have confirmed the role of infections as a cause of miscarriage especially in the second trimester of pregnancy; however, their role in the first trimester miscarriages remains unclear [69–74].
