**5. Conclusion**

GBC represents a major challenge in oncology. The only curative treatment for this disease is surgical resection. The roles of radiation and chemoradiation in the neoadjuvant and adjuvant settings remain to be defined in prospective studies. Bilcap study demonstrated that capecitabine improved overall survival in adjuvant situation. The treatment of metastatic forms is to be discussed according to the general condition (PS, age). In case of PS > 2, it is recommended to do exclusive support care. For patients with PS between 0 and 2, it is the indication of a palliative CT by gemcitabine-cisplatin. The GEMOX scheme represents an alternative.
