**2.2 CD96**

CD96 is a member of the immunoglobulin superfamily, a transmembrane glycoprotein, and a T-cell surface-specific receptor 6. By using blood samples from 55 patients with AML, Du et al. found that CD96 (>10%)-enriched patients showed a poor response to chemotherapy [20]. Of note, CD96 was proved to be an efficient identical marker of LSCs in CD34+ CD38<sup>−</sup> groups.
