**Author details**

*Advances in Hematologic Malignancies*

**5. Conclusion**

ized treatment strategies.

**Conflict of interest**

The authors declare no conflicts of interest.

activity regulation connected to the progression of disease and regulation of pathological events [12–14]. Focusing on such specific modifications presents key opportunities to further facilitate efficient and precise drug strategy design [55–58]. Inhibition of protein kinases associated with key phosphorylations has been an intense research topic in the last decade [67–69, 72, 73, 75]. Significant progress in protein mass spectrometry techniques, specific antibody design and development, parallel studies of genes, epigenetic proteome, and related proteins including their disease-related modifications altogether open a new horizon for a more sensitive and personalized approach to the diagnosis and treatment methods of CLL and ALL. The combination of such approaches should further facilitate the development of more efficient drugs and approaches which more specifically target the key signaling events concerning the onset and progression of the disease. Based on the fact that proteome maps are unique to each individual, there is an urgent need for personalized diagnostics and a personalized molecular treatment approach. Using the information from the proteins associated with the CLL and ALL, and the misregulation of signaling pathways in associated cell regulation events, the precise and detailed protein signaling outcome can form the base of potential success in the domain of efficient drug design and consequent molecular treatment, without the typical side effects of current conventional methods.

Given the diverse molecular and genetic alterations occurring in both CLL and ALL, it is unlikely that a single and unique therapeutic approach will be effective across all patients. Great progress has been made thus far in the identification of oncogenic drivers and therapeutic targets. However, although treatment regimens have advanced significantly, they continue to present many challenges for the majority of patients, including toxicity. Future studies focused on the identification of biomarkers should result in more effective treatments exhibiting antileukemic activity with reduced toxicity. Furthermore, highly targeted therapy can be expected to lead to improvements in remission and survival as part of individual-

**86**

Martina Maďarová1 , Dominik Dobransky2 and Tomas Dobransky1 \*

1 DB Biotech Inc., Košice, Slovakia

2 BLES Biochemicals Inc., London, ON, Canada

\*Address all correspondence to: tdobransky@dbbiotech.com

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
