**8.1 Proteasome inhibitors**

The proteasome is a gigantic highly sophisticated protease complex that degrades unneeded or damaged proteins by proteolysis. As such, the proteasome plays an important role in critical cellular processes including proliferation, differentiation, cell cycle progression and survival DNA repair, angiogenesis and apoptosis [63]. Three proteasome inhibitors, carfilzomib, bortezomib and ixazomib are approved by FDA and oprozomib and other agents are in the clinical trials late stages.

**Figure 1.** *History of multiple myeloma treatment.*
