**Meet the editor**

Dr. Andrew B. Lemmey, BSc (Hons), MA, PhD, is a clinical exercise physiologist in the School of Sport, Health and Exercise Sciences at Bangor University in the UK He has a 14 year background in leading groundbreaking research into restoring physical function and attenuating disabilities in patients with rheumatoid arthritis (RA). His expertise in this field was recognized by the Ameri-

can College of Sports Medicine, who invited him to author the chapter on arthritis in their influential text "Clinical Exercise Physiology (3rd Ed.)" (Human Kinetics). Dr. Lemmey has over 50 peer-reviewed publications, is a regular speaker at international conferences, and is a member of the British Society for Rheumatology. After gaining his PhD from the University of Adelaide, Dr. Lemmey was a post-doctoral research fellow at Cambridge and Bristol prior to accepting his current academic post at Bangor.

Contents

**Preface IX** 

Takashi Usui

Chapter 1 **Cytokine Profile of T Cells in the Joints** 

Evin Sowden and Wan-Fai Ng

Chapter 3 **IL-12 Family Cytokines in Inflammation** 

and Slawomir Maslinski

Chapter 2 **Invariant Natural Killer T Cells in Rheumatoid** 

**of Rheumatoid Arthritis and Its Murine Models 3** 

**Arthritis and Other Inflammatory Arthritides 19** 

**and Bone Erosion of Rheumatoid Arthritis 41**  Ran Wei, Alastair J. Sloan and Xiao-Qing Wei

**Experiments** *In Vitro***: A Change of Conception? 59** 

Chapter 4 **The Role of Neutrophils in Rheumatoid Arthritis –** 

Michal Gajewski, Przemyslaw Rzodkiewicz

Chapter 5 **Molecular Mechanisms of Rheumatoid Arthritis Revealed by Categorizing Subtypes of Fibroblast-Like Synoviocytes 73**  Katsuhiko Ishihara and Hideya Igarashi

> **Fibrin Deposits Contribute to Invasion 111**  Olga Sánchez-Pernaute, Antonio Gabucio, Astrid Jüngel, Michel Neidhart, María Comazzi,

Gabriel Herrero-Beaumont, Renate E. Gay and Steffen Gay

Chapter 6 **Lysosomal Glycosidases in Degradation of Human Articular Cartilage 97**  Janusz Popko, Tomasz Guszczyn, Sławomir Olszewski, Krzysztof Zwierz

Chapter 7 **Innate Mechanisms of Synovitis –** 

**Part 1 Etiology 1** 
