**10. Conclusion**

The term used to describe lifelong changes in function that follow a particular event in an earlier period of the life span is called programming. Nevertheless, the previous information may have a significance of pediatric obesity endocrine abnormality. GH-IGF-1 axis is partially responsive for the signal to enhance muscle and bone development. Growth hormone (GH) response to exercise may be weak in obesity and may not appear until later in life, especially if they affect genes that are responding to subsequent environmental responses, such as high-fat diet. I do not know how the genetic change instigated development window in the main systems. Exercise is the best way to do this when you exercise regularly, and you build stronger muscles, even if you do not work out with weights. Muscles use more calories than fat throughout the day, even while you are resting. Fat cells of unhealthy obese were larger than those of any other group. It was swollen and full of inflammation. The collapse and filling of their fat stores were disabled and showed a closer look that their mitochondria were not functioning well causing loss of muscle power. This is due to fat cell accumulation which reduces its ability to burn fuel and produce adenosine triphosphate, or ATP, the body's energy currency. It is natural that the behavior of the human being and his attitude of life inert to be aware of the importance of physical activity and live in the healthy lifestyle system in the prenatal stages. Thus, healthy genetic modification will be inherited for future generations.
