**1. Introduction**

*CYP11B2* enzyme is one of the enzymes in the pathway of steroidogenesis and responsible for the catalysis of the last three steps in the aldosterone biosynthetic cascade. It is encoded by *CYP11B2* gene located on human chromosome 8q21-22. The genetic element of cardiovascular disorders has been emerged as a risk factor for the progression of these disorders. Among these genetic elements, *CYP11B2* genetic variants and haplotypes play a pivotal role in the susceptibility, progression, survival, and therapeutic response of many cardiovascular disorders such as hypertension, coronary heart disease (CAD), atrial fibrillation (AF), cardiomyopathy, heart failure (HF), and other disorders. It was suggested to influence the cardiovascular system via alteration of aldosterone production, which acts either directly on the heart or systemically via stimulating sodium and water reabsorption and increasing the blood pressure.
