**1. Introduction**

Nephrotic syndrome is a general type of kidney disease seen in children. Historically, Roelans is credited with the first clinical description of nephrotic syndrome in the late fifteenth century. Nephrotic syndrome is appropriate to excessive hypoalbuminemia, proteinuria, and edema, although additional clinical hyperlipidemia is also usually present. The beginning of adrenocorticotropic hormone and cortisone in the 1950s contributed to an even greater decrease in mortality (to 9%), which was noted to occur in association with dramatic resolution of proteinuria.
