Regardless of tumour number, size or location

DS=Diffuse seeds, FS=Focal seeds, SRF=Sub retinal fluid, SRS=Sub retinal seeds, T= Tumour, VS=Vitreous seeds, NA= Not applicable because these patients had primary enucleation.

4. International retinoblastoma classification

It is useful in guiding the selection of the most appropriate treatment methods and predicting chemo reduction success.-**15**,**16**

Retinoblastoma – An Update on Clinical, 8 Genetic Counseling, Epidemiology and Molecular Tumor Biology

Group C. Localized seeding of the vitreous or under the retina <6.00mm (0.2inch) from the

Group D. Widespread vitreous or sub retinal seeding which may have total retinal

3. Philadelphia Practical Grouping System of Retinoblastoma Based on Clinical Features.-

To quantify retinoblastoma and its associated features without need to refer to complex qualification criteria. Proceeding from the lowest to the highest grouping is meant to imply worse ocular prognosis. This is a simpler and newer classification to Reese-

Group Abbreviations Features success\* 1. T Tumour only# 100% 2. T+SRF Tumour + subretinal fluid 91%

59%

12%

NA

SRS ≤ 3mm from tumor VS ≤ 3mm from tumor

SRS >3mm from tumor VS > 3mm from tumor

a. Neovascular glaucoma

b. Opaque media from hemorrhage

\*success after treatment with systemic chemotherapy with or without local consolidation is defined as

It is useful in guiding the selection of the most appropriate treatment methods and

DS=Diffuse seeds, FS=Focal seeds, SRF=Sub retinal fluid, SRS=Sub retinal seeds, T= Tumour, VS=Vitreous seeds, NA= Not applicable because these patients had primary enucleation.

c. Invasion of post laminar optic nerve, choroid (<2mm), sclera, orbit or anterior chamber.

a. Massive seeding involving over half of retina

To predict the preservation of the eye using all modern therapeutic methods

Group A. Small tumours <3mm (about 0.1 inch) confined to the retina

b. Vitreous seeding

original tumour

detachment

**Others** 

**14**

Ellsworth.

2. ABC classification of retinoblstoma-**5** 

Group B. Larger tumours confined to the retina

Group E. No visual potential, eye cannot recover

3. T + FS Tumour +focal seeds

4. T +DS Tumour +diffuse seeds

5. High Risk Tumor plus(any one)
