*5.1.1.2 Platelet-derived growth factor (PDGF)*

Platelets, monocytes, and endothelial cells are responsible for production of PDGF. They recruit various inflammatory cells at the fracture site resulting in increased cellular proliferation and collagen deposition. The potential use of PDGF has been suggested in the treatment of osteoporosis and bone healing. It is thought that recombinant PDGF-BB form assists to release the pericytes from the abluminal side to release free and activated MSCs [47, 48].
