**5. Conclusions**

 Given the growth of the products derived from medicinal plants in Brazil, it was necessary to implement a statute that covered the requirements for all medicines and biomaterials to ensure the quality, efficacy, and safety of these products. Based on the researches, *C. multijuga,* in the form of copaiba oil, was an effective agent against the etiological agents of caries disease. Copaiba oil emulsions as dentin biomodifiers with their properties of antibacterial activity and inhibition of MMPs may contribute to the stability of the hybrid layer in caries-affected dentin treated with this emulsion.

 Propolis demonstrated an effective and controlled inflammatory response in the periodontal tissue such as the absence of bone resorption, blood vessels without congestion, and presence of dense gingival fibers.

The *L. ferrea* extract showed antibacterial activity against the oral microorganisms tested, and satisfactory stability and quality, enabling the formulation of a mouthwash using this extract to control dental biofilm. The results demonstrated that the *L. ferrea* mouthwash was shown to be free of contamination for the tested microorganisms and was within the standards of safety demanded for/to allow its use.

 As propolis showed a reduction in bone resorption, and the other medicinal plants studied were in compliance with the safety standards, future investigations into the effectiveness of adding these herbal medicines to bone substitutes will be conducted. Via an effective biodegradation delivery system, the release of phytotherapic agents is expected to promote the growth of bone tissue. Pharmacological tests will examine the phytotherapic ability to generate an osteotropic effect, stimulating bone cell proliferation and differentiation while decreasing osteoclast activity. Thus, future studies will be in search of herbal devices that stimulate the innate regenerative capacity of bone and can be used in the regeneration of bone tissue.
