**7. Role of neutrophil in coagulation in sepsis**

In sepsis, the early cytokine storm shows up at intervals of 30–90 minutes during lipopolysaccharide (LPS) layer exposure. The following stage comprises the activation of neutrophils and nitrous oxide, further cytokine discharge, and the formation of kinins, complement protein products, lipid mediators [55, 56], and the tissue response to disease is started by expression of cellular adhesion particles. Neutrophils are basic cell arbiters not just discharging proteolytic catalysts, but additionally producing responsive oxygen species, including myeloperoxidase (MPO), neutrophil elastase, and cathepsin G. Neutrophils discharge also neutrophil extracellular traps that instantiate extracellular chromatin threads with strong cytotoxic effects, containing both histones and granular proteins, which have bactericidal properties [57]. Also, neutrophil extracellular traps have prothrombotic properties, including activation of platelets, energizing of thrombin generation, and downregulation of anticoagulant pathways by the upgrade of APC resistance [58].
