**Abstract**

Mycotoxins are secondary metabolites synthesized by filamentous fungi. They are common food contaminants that cause mycotoxicosis in humans and animals. Due to the severity of health risk pose by these mycotoxins, many countries have enacted strict measures to curb this menace. One promising measure is the use of nanoparticles. Herein, we present an overview of the application of titanium dioxide, chitosan, ultradisperse humic sapropel suspension, and carbon-based nanoparticles, a novel and innovative method of reducing mycotoxin production and the subsequent contamination of grains. All nanoparticles considered enhanced cell permeability by disrupting the membrane, resulting in the outflow of cellular materials. However, concentration, volume, type, and illumination (sunlight) influenced the fungicidal potential of NPs.

**Keywords:** filamentous fungi, mycotoxins, nanoparticles, fungicide, reactive oxygen species
