**Treatment**

Plasmapheresis is the recommended therapy. Plasmapheresis removes platelet-aggregating substances causing TTP. Treatment is 90% successful with TTP but is less successful with HUS. Steroids are used along with plasmapheresis. However, steroids are less effective than plasmapheresis (25% response rate).Platelet transfusions should be avoided when possible because they can cause a clinical deterioration. Platelet transfusions should be used only for uncontrolled bleeding or intracranial hemorrhage. Other therapies include immunosuppressive agents (vincristine, azathioprine, cyclosporine)and splenectomy for TTP. Premature termination of pregnancy has been associated with relapse. Delivery should be considered only when no response to other therapies occurs. (George JN, 2010)
