**2. Conclusion**

 Numerous polymeric constructs have been used in combination with growth factors for engineering and regeneration of tissues. This combination of polymer and growth factors for tissue repair depends largely on using biodegradable materials that can stimulate specific cellular responses at a molecular level which should be suitable, simple and cost-effective. Our data in this section offers pharmacological evidence on the potential use of the mentioned plant extracts in bone fracture, cartilage regeneration and wound treatment. In fact, medicinal plants found to have anti-inflammatory properties may partake in host modulatory therapy for various inflammatory diseases as proposed in [3, 39].

 We would like to state that the herbs and all the substances in this study are for cartilage defects of grades 1, 2 and 3 according to outerbridge scale. Therefore, if congenital or after trauma large cartilage case is presented, then operative treatment is advised.
