**5.1 Familial**

The familial clustering of PPCM is well known; it could be due to genetic or environmental factors. Ancestry with African genomics may be a risk factor and explains the higher prevalence of PPCM in Haiti, Africa, and black women in other countries. The guanine nucleotide-binding protein beta-3 (GNB3) subunit has a polymorphism called C825T. This polymorphism is associated with an increased risk of hypertension, low plasma renin, and cardiac remodeling. GNB3 has a prevalence of 50% in black individuals compared with 10% in white individuals [12].
