**Abstract**

Introduction: *Staphylococcus aureus* is a Gram-positive coconut that causes various life-threatening infections and, in turn, represents a major producer of healthcare-associated infections. This pathogen is highly resistant to antibiotics, which has made it difficult to eradicate in recent decades. Photodynamic therapy is a promising approach to address the notable shortage of antibiotic options against multidrug-resistant *Staphylococcus aureus*. This therapy combines the use of a photosensitizing agent, light, and oxygen to eradicate pathogenic microorganisms. The purpose of this study is to provide relevant bibliographic information about the application of photodynamic therapy as an alternative antimicrobial therapy for *Staphylococcus aureus* infections. Methods: This review was achieved through a bibliographic search in various databases and the analysis of relevant publications on the subject. Results: A large body of evidence demonstrates the efficacy of photodynamic therapy in eliminating biofilm- or biofilm-producing strains of *Staphylococcus aureus*, as well as antibiotic-resistant strains. Conclusion: We conclude that photodynamic therapy against *Staphylococcus aureus* is a recommended antibacterial therapy that may complement antibiotic treatment.

**Keywords:** photodynamic therapy, *Staphylococcus aureus*, antibiotic resistance
