**5.5 Accumulation in the body**

Zoledronic acid and denosumab have similar potency of inducing osteonecrosis. They are different in the time of accumulation in the body. Bisphosphonates accumulate in bones, where they persist for a long time, their half-life last up to 11.2 years,

while unlike bisphosphonates, denosumabs do not accumulate in the bones and are eliminated from the body after only 6 months [28, 46].
