**4.1 Inhibition of bone resorption and remodeling**

Antiresorptive medications inhibit osteoclast function and differentiation, leading to their apoptosis, and this results in reduced bone remodeling [31]. In addition to acting on osteoclasts, antiresorptive medications also reduce the activity of osteoblasts, keratinocytes and fibroblasts [32, 33]. Of all the bones, the jaws are the most susceptible to remodeling, so osteonecrosis specifically occurs on them.
