Meet the editors

Professor Dr. med. Hubertus Himmerich is a Clinical Senior Lecturer in Eating Disorders at King's College London and a Consultant Psychiatrist on an inpatient ward for patients with eating disorders at the Bethlem Royal Hospital in London, UK. He received his scientific and clinical training at the Max-Planck-Institute of Psychiatry in Munich and the Universities of Mainz and Marburg, Germany. In 2009 he was appointed Professor for

Neurobiology of Affective Disorders at the University of Leipzig, Germany. His scientific focuses include appetite regulation, psychoimmunology, and military mental health. He has led and performed national and international scientific projects with researchers from Europe, Australia, and North America, and has published more than 130 articles in peer-reviewed scientific journals as well as a number of books and book chapters.

Ignacio Jáuregui-Lobera MD, PsyD, MSc is Director of the Behavioural Science Institute (Seville, Spain) and Associate Professor at Pablo de Olavide University (Seville, Spain). He is the director of the postgraduate course in Eating Disorders and Obesity at the same university. Dr. Jáuregui-Lobera developed his career as a psychiatrist, family practitioner, and psychologist, working in the field of eating disorders and obesity since 1993. He is author of

several books and book chapters and more than 100 scientific articles.

Contents

**Section 1**

of Body Image

**Section 2**

*by Ashley Higgins*

Implications

**Preface III**

Dissatisfaction **1**

**Chapter 1 3**

**Chapter 2 23**

**Chapter 3 35**

and Novel Drug Targets **49**

**Chapter 4 51**

**Chapter 5 69** Possible Dysregulation of Orexin and Dopamine Systems in Anorexia Nervosa

**Chapter 6 87**

Features and Symptoms: Impulsivity, Compulsivity, Ambivalence and Body

Impulsivity and Compulsivity in Anorexia Nervosa: Cognitive Systems Underlying Variation in Appetite Restraint from an RDoC Perspective

Bulimia Nervosa and Body Dissatisfaction in Terms of Self-Perception

*by Layam Anitha, Asma Abdulaziz Alhussaini, Hessah Ibrahim Alsuwedan,*

*by Natalia Solano-Pinto, Miriam Valles-Casas and Raquel Fernández-Cézar*

The Neurobiology of Anorexia Nervosa: Insights into Pathophysiology

Dysbiosis of the Microbiota in Anorexia Nervosa: Pathophysiological

*by Magnus Sjögren, Stein Frostad and Kenneth Klingenberg Barfod*

*by Samantha Jane Brooks and Helgi Schiöth*

*Hessa Faleh Alnefaie, Rehab Abduallah Almubrek*

Bulimia Nervosa: Is Body Dissatisfaction a Risk Factor?

*by Marcela Morales-Mulia and Sandra Morales-Mulia*

*and Shima Abdulaziz Aldaweesh*

The Neurobiology of Anorexia Nervosa

## Contents



Preface

Although anorexia and bulimia nervosa are two distinct mental illnesses, they are both eating disorders that share common clinical features and symptoms, including the pursuit of weight loss and dissatisfaction with and misperception of body image. They are frequently associated with the same comorbidities, which include affective and anxiety disorders. Therefore, it seems only natural to explore and

This book is divided into four sections. The first section addresses clinically relevant features and symptoms in anorexia and bulimia nervosa. The second section is concerned with the neurobiology of anorexia nervosa and provides novel insights into its pathophysiology and the development of novel medications that target the microbiome for the treatment of eating disorders. The third section focusses on the perspectives of patients and their caregivers, and on family support. The final section highlights and discusses specific aspects related to the clinical management

We are proud to announce that this book has received international contributions from Denmark, India, Mexico, Saudi Arabia, Spain, the United Kingdom, and the United States of America; and we thank all authors for their contributed chapters,

Behavioural Science Institute and University of Pablo de Olavide of Seville,

**Hubertus Himmerich**

King's College London,

**Ignacio Jáuregui-Lobera**

London, UK

Seville, Spain

Department of Psychological Medicine,

We would also like to thank IntechOpen and, specifically, Ms. Ivana Barac, Ms. Martina Brkljačić, and Ms. Martina Jošavac for making this book possible.

discuss these closely related diagnoses within the same volume.

of patients with anorexia and bulimia nervosa.

which are both informative and offer inspiration.
