**3. Treatment of limb ischemia**

Traditionally, 6 hours are recommended as a golden period for intervention in limb ischemia. In a series analysing limb ischemia in ECLS patients an additional retrograde reperfusion within 6 hours of onset of symptoms avoided amputations completely, whereas the same procedure after that period was burdened with a 20% amputation rate or permanent neurological deficit [34]. Therefore, every attempt should be made to re-establish adequate blood supply in the ischemic limb as soon as possible to avoid catastrophic consequences and residual damage (**Table 2**).
