*2.5.2.2 Passive immunoprophylaxis*

Passive immunoprophylaxis has been explored in solid organ transplantation in a number of randomized trials, whereby hyperimmune globulin provided significant overall protection from severe disease, with a reduced rate of CMV disease to approximately half of that seen in the placebo groups. Intravenous treatment is generally less convenient for the patient and health-care provider and carries the theoretical risk of transmitting blood-borne viruses [39].
