**1. Introduction**

Delirium following transplantation is a wide reaching problem that has a significant effect on recovery time, functional outcomes, and has a profound economic impact on the healthcare system. Delirium is now being recognized as a major driver of poor health care related outcomes. Post-operative delirium has been shown to be associated with longer length of stays, increased post-operative complications, increased readmission rates, higher costs, longer periods of mechanical ventilation, prolonged cognitive impairment and increased mortality [1, 2]. With this in mind, early diagnosis of delirium, treatment of potential contributing factors, and optimized management is paramount to improve post-transplant outcomes. This chapter will highlight a proactive approach to delirium management and prevention in the abdominal transplant population.
