*2.5.2.1 CMV matching*

Theoretically, a method of minimizing the risk of CMV infection would be to avoid transplantation of a seropositive organ into a seronegative recipient. Historically, before the advent of antiviral prophylaxis, many units avoided transplanting CMV-positive solid organs into CMV-negative recipients. However, given the shortage of donor organs, such an approach is difficult to practice in these settings.

One area in which CMV matching remains relevant is in the elective use of blood products. Where it is known that both donor and recipient are seronegative for CMV, leukodepleted blood and blood products are available and should be used to minimize the risk of primary infection [39].
