**5. Conclusion**

HCC is a deadly malignancy either in cirrhotic and non-cirrhotic patients. A well-timed follow-up and detection of patients at risk are fundamental, since diagnosis at early stage allows more aggressive and effective treatments. HCC in non-cirrhotic liver will be more often diagnosed, particularly in the case of NASH and NAFLD, because they are followed up more strictly.

In recent years, indications to surgery have not changed substantially, while a lot has been introduced in terms of imaging, which is nowadays an essential support in preoperative planning, intraoperative guide and postoperative follow-up. Staged hepatectomy techniques have shown interesting results and will become part of clinical practice in the future, especially in treatment of non-cirrhotic patients. Surgery remains the most effective treatment against HCC, since complete resections allow important survival benefits at 3, 5 and 10 years.

**91**

**Author details**

Stefania Brozzetti1

Leonardo Luca Chiarella1

Sapienza, Rome, Italy

Rome La Sapienza, Rome, Italy

provided the original work is properly cited.

\*, Simone Bini1

, Katia Fazzi1

\*Address all correspondence to: stefania.brozzetti@uniroma1.it

, Chiara D'Alterio1

2 Deparment of Radiological Sciences, Policlinico Umberto I, University of Rome La

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

1 Department of Surgery "Pietro Valdoni", Policlinico Umberto I, University of

and Michele Di Martino2

, Chiara De Lucia1

,

*HCC in Cirrhotic and Non-cirrhotic Liver: Timing to Surgery and Outcome - State of the Art*

*DOI: http://dx.doi.org/10.5772/intechopen.86638*

*HCC in Cirrhotic and Non-cirrhotic Liver: Timing to Surgery and Outcome - State of the Art DOI: http://dx.doi.org/10.5772/intechopen.86638*
