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## Meet the editor

Dr. Zhan He Wu graduated from Harbin Medical University, China, and received his Master's degree in 1985 from the same university*.* He received his PhD degree in 1993 from the University of New South Wales, Australia. Since 1996, he has been working in the field of human genetic

disease studies in the Sydney Genome Diagnostics, Western Sydney Genetics Program, The Children's Hospital Westmead,

Affiliated to the University of Sydney, mainly on hematological malignancies such as leukemia and lymphoma, and inherited bone marrow failure syndromes, including Fanconi anemia (it is named as the prone cancer syndrome and paradigm for cancer and aging research).

Dr. Zhan He Wu has published more than 60 original articles, more than 60 scientific conference presentations, and five chapters in books. He was granted as a Founding Fellow of Royal College of Pathologist for Australasia in 2011. In the past he has organized many national scientific conferences. He was invited as the Chair for the Euro-Global Conference on Pediatrics and Neonatology 2018, 13–15, SEP, ROME, and delivered the welcome message as well. He has been involved in medical journal reviewing and editing and invited by nine international journals as reviewer, associate editor, guest editor, editor, column chair, and so on. Currently, he is editing two professional books in English for a UK publisher: *Germ Line Mutations Associated Leukemia* and *Rare Diseases*.

Contents

**Section 1**

*by Zhan He Wu*

**Section 2**

Therapeutics

**Section 3**

**Section 4**

*by Arturo Solis Herrera*

**Preface III**

Introduction **1**

**Chapter 1 3**

Epigenetic Mechanisms Associated Leukemia **11**

**Chapter 2 13**

Germ Line Mutations Associated Leukemia **33**

**Chapter 3 35**

Energy Failure and Leukemia **51**

**Chapter 4 53**

Perturbations in Generation and Flow of Energy in the Eukaryotic Cell

Introductory Chapter: Germline Mutations Associated with

Leukaemia - Different Genetic Landscape and Therapeutic Strategies

Epigenetic Landscape in Leukemia and Its Impact on Antileukemia

Familial Leukemia Associated with Thrombocytopenia

Explain the Chromosomal Instability Syndrome

*by Jakub Trizuljak and Michael Doubek*

*by Bingzhi He, Julia Cathryn Hlavka-Zhang, Richard B. Lock and Duohui Jing*

### Contents


Preface

Evidence obtained from studies over the last decade has demonstrated that some types of hematological malignancies, commonly in acute myeloid leukemia and myelodysplastic syndrome, are associated with germ line mutations either in specific gene mutations or genetic-based syndromes, as described and classified officially by the World Health Organization (WHO) in their book *WHO Classification* 

The four edited chapters in this book are specific to our aim of increasing the awareness, minimizing the underdiagnosis and even misdiagnosis, preventing the occurrence of secondary malignancies, and providing the appropriate treatment strategies for germ line mutations-associated leukemia. This includes the selection of donors for stem cell transplantation and also care for members of affected families by the application of modern technologies. This is because germ line mutationsassociated leukemia presents different genetic landscapes and more importantly it requires different therapeutical strategies due to the nature and complexity of the disease. We hope this book will help in the understanding of germ line mutationsassociated disease, particularly in leukemogenesis caused by somatic mutations.

Books published on the topic of somatic mutations-associated leukemia are very common, but to our knowledge books published on the topic of germ line mutations-associated leukemia are extremely rare, so far. We all are facing huge

We would like to express our thanks for the contributions from all the experienced

Epigenetics is the concept of genetic functional modification and plays a very important biological role in the control of gene expression without changing the DNA sequence. Studies have found that epigenetics is associated with cancer. Dr. Duohui Jing, Dr. Richard B Lock, Dr. Julia Cathryn Hlavka-Zhang, and Dr. Bingzhi He have contributed their chapter "Epigenetic Landscape in Leukemia and Its Impact on Antileukemia Therapeutics" in which they discuss their novel findings obtained from first-hand studies on the mechanism of therapeutical resistance from

As mentioned above, WHO has specifically described and classified the myeloid neoplasmas with germ line predisposition and pre-existing platelet disorders. Dr. Jakub Trizuljak and Dr. Michael Doubek have contributed their chapter "Familial Leukemia Associated with Thrombocytopenia" by discussing the association of familial/inherited platelet disorders with germ line mutations-associated leukemia.

Dr. Arturo Solis Herrera has contributed his chapter "Perturbations in Generation and Flow of Energy in the Eukaryotic Cell Explain the Chromosomal Instability Syndrome" from different fields and directions to discuss the association of the

challenges but also exciting opportunities in such a special field.

authors as follows:

specific epigenetic modification.

pathological mechanism of leukemia.

*of Tumors of Haematopoietic and Lymphoid Tissues*, 2016.
