**Chapter 6**

*Cystic Fibrosis - Heterogeneity and Personalized Treatment*

[58] Arkwright P, Pravica V, Geraghty P,

et al. End-organ dysfunction in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine.

[59] Bandsma R, Bozic M, Fridell J, et al. Simultaneous liver-pancreas transplantation for cystic fibrosisrelated liver disease. A multicenter experience. Journal of Cystic Fibrosis.

[60] Nash K, Collier J, French J, et al. Cystic fibrosis liver disease to transplant or not to transplant? American Journal of Transplantation. 2008;**8**:162-169

[61] Young A, Giles C, Mervyn T, et al. A combined liver-pancreas en-bloc

transplant in a patient with cystic fibrosis. Transplantation.

2003;**167**:384-389

2014;**13**:471-477

2005;**5**:605-607

2017;**9**:CD000222. DOI:

MPG.0b013e3182432034

et al. Liver cirrhosis and portal hypertension in cystic fibrosis.

[53] Stonebraker J, Ooi C, Pace R, et al. Features of severe liver disease with portal hypertension in patients

with cystic fibrosis. Clinical Gastroenterology and Hepatology.

[54] Arnon R, Annunzjato R, Miloh T, et al. Liver and combined lung and liver transplantation for cystic fibrosis: Analysis of the UNOS database. Pediatric Transplantation.

[55] Freeman AJ, Sellers ZM,

approach to pretransplant and posttransplant management of cystic fibrosis-associated liver disease. Liver Transplantation. 2019;**25**(4):640-657.

[56] Frost F, Dyce P, Ochota A, et al. Cystic fibrosis related diabetes:

multidisciplimaty approach. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019;**12**:545-552.

DOI: 10.1002/lt.25421

Optimizing care with a

DOI: 10.2147/DMSO.S180597

[57] Gan HW, Bhatt JM, Denvir L, et al. Monogenic diabetes mellitus in cystic fibrosis. Archives of Disease in Childhood. 2019;**104**(9):887-889. DOI: 10.1136/archdischild-2018-316141

Mazariegos G, Kelly AA. Multidisciplinary

2016;**14**(8):1207-1215

2011;**15**:254-264

10.1002/14651858.CD000222.pub4.

[51] Pereira T, Lewindon P, Greer R, et al. Transcriptional basis for hepatic fibrosis in cystic fibrosis- associated liver disease. Journal of Pediatric Gastroenterology and Nutrition. 2012;**54**(3):328-335. DOI: 10.1097/

[52] Efrati O, Barak A, Modan-Moses D,

European Journal of Gastroenterology & Hepatology. 2003;**18**:1073-1078

**90**
