**1.2 Organ lesions contributing to the manifestation of CFLD**

In the examination of Wilchanski et al., the presence of hepatic lesions (cystic fibrosis liver damage (CFLD)) was concluded in 28% (80/288) of CF patients. All patients with hepatic lesions were diagnosed with pancreatic insufficiency. No correlation between the occurrence of hepatic lesions and pulmonary lesions, respiratory insufficiency, the level of malnutrition, meconium ileus, and/or distal intestinal obstruction syndrome (DIOS) was concluded [24]. Lindblad observed meconium ileus in only 12% of CF patients, out of whom only 6/15 patients with meconium ileus had the symptoms of liver damage [6]. Siano did not prove the correlation between the occurrence of hepatic lesions in the course of cystic fibrosis and the pancreatic efficiency and the level of nutrition. In 2–5% of patients, focal biliary cirrhosis develops into multilobular cirrhosis [25].
