*1.2.4 Cholelithiasis*

Cholelithiasis concerns 14–24% of CF patients. The following play a role in the pathogenesis of the formation of gallstones: abnormal bile content, increased excretion of bile acids with stools, and the formation of lithogenic bile where bile acids are interlocked with glycine. No correlation between the formation of gallstones and supplementation with pancreatic enzymes has been confirmed [1, 3, 22]. Risk factors for the development of liver diseases in cystic fibrosis:

1.Male gender—three fourths of patients with CFLD are male. Protective role of


estrogens in female.

5.Severe genotype (delta F508) [1, 12, 24, 35, 36].
