**1. Introduction**

Hepatic lesions concern only 5–20% of patients with diagnosed cystic fibrosis. However they increase the level of fatalities, shorten the survival rate, and impair the quality of life. Liver diseases are the most common, non-pulmonary cause of death among patients with cystic fibrosis. They most often occur in the first decade of life. Cirrhosis is detected in about 10% of CF children under the age of 18 compared to 2% of adults with the same condition. The average age of the CF liver disease manifestation is about 10 years [1–7].
