Meet the editors

Dennis Wat, MD, obtained his undergraduate degree (MB BCh) in 1998 in Cardiff, UK. In 2007, he was awarded an MD from the University of Cardiff where he researched the impact of respiratory viruses in cystic fibrosis (CF). In 2009, he was appointed as Respiratory Consultant in the Adult CF Unit at Papworth Hospital, Cambridge, UK. In 2012, he moved to Liverpool, UK to join the respiratory community and Liverpool Adult CF services.

Apart from CF, Dr. Wat has vast experience in the management of COPD, bronchiectasis, asthma and oxygen therapy in the management of chronic lung diseases. He has published widely in pulmonary medicine, including papers in peer-reviewed journals and book chapters. He is a principal investigator in a number of clinical trials.

Dr Dilip Nazareth became interested in a career in cystic fibrosis after training as a Junior Doctor at the Royal Brompton Hospital in London. He subsequently undertook his higher training posts in respiratory and general medicine in Merseyside. He spent a further 2 years as a Clinical and Research Fellow at the prestigious Adult Cystic Fibrosis (CF) Unit at Liverpool Heart and Chest Hospital, which is among the largest CF units in the country. During

this time, he carried out research on Cystic Fibrosis Related Diabetes (CFRD), and completed his (Doctoral) MD thesis through the University of Liverpool. Following completion of his training, he worked as a consultant in CF, respiratory and general medicine at University Hospitals Bristol NHS Trust, prior to relocating back to Merseyside. His research interests are in CFRD, CF renal disease, CF microbiology and CF antibiotics. He has published several scientific articles in respiratory medicine and CF and continues to undertake research. He previously was a Research Affiliate at the National Institute for Health - Research Biomedical Research (University of Bristol) and a member of the British Thoracic Society CF Specialist Advisory Group. He is also an International Examiner and Examination Chair for the postgraduate medical examinations of the Royal College of Physicians, London.

Contents

with Cystic Fibrosis *by Salah Abdelbary*

*by Sabina Wiecek*

**Preface XI**

**Chapter 1 1**

**Chapter 2 23**

**Chapter 3 37**

**Chapter 4 53**

**Chapter 5 79**

**Chapter 6 91**

**Chapter 7 105**

Recent Approach in Microbial Pathogen Complications in Patients

The Pulmonary Microbiome in Cystic Fibrosis *by Freddy J. Frost, Dilip Nazareth and Dennis Wat*

Overview of CFTR Modulators and Gene Therapy *by Catherine Rang, Tom Kotsimbos and John Wilson*

Evaluating Clinical Effectiveness with CF Registries

Video Call Educational Program for Cystic Fibrosis Adolescents

Designing Heterogeneous-mHealth Apps for Cystic Fibrosis Adults *by Tamara Vagg, Cathy Shortt, Claire Fleming, Mairead McCarthy,* 

*by Annalisa Fogazzi, Fabianna Timelli, Annalisa Vezzoli,* 

Liver Changes in the Course of Cystic Fibrosis

*by Rhonda Szczesniak and Bin Huang*

*Valentina Tradati and Rita Padoan*

*Sabin Tabirca and Barry J. Plant*
