Meet the editor

Dr. Denis Larrivee is a visiting scholar at the Mind and Brain Institute, University of Navarra Medical School and Loyola University, Chicago, and has held professorships at Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University's Medical School he received the Association for Research in Vision and Ophthalmology's first place award for studies on photoreceptor degenerative

and developmental mechanisms. He is the editor of a recently released text on brain computer interfacing with IntechOpen Publishing and an editorial board member of the journals *Annals of Neurology and Neurological Sciences* (USA) and *EC Neurology* (UK). An International Neuroethics Society expert he is the author of more than 75 papers and book chapters on such varied journals/venues as *Neurology and Neurological Sciences* (USA), *Journal of Neuroscience*, *Journal of Religion and Mental Health*, and *IEEE Explore*. In 2018 he was a finalist in the international Joseph Ratzinger Expanded Reason award.

Contents

**Section 1**

**Section 2**

Top-Down Strategic Analysis

*by Denis Larrivee*

*by José V. Pardo*

Alzheimer Drug

**Section 3**

*by Stavros J. Baloyannis*

*by Fakhra Amin and Bilqees Bano*

Non-pharmacological Treatment of Alzheimer's

*by Terezia Fertalova and Iveta Ondriova*

Healthcare Models in Alzheimer's Disease

**Preface III**

Thematic Issues in Modern Alzheimer Research **1**

**Chapter 1 3**

Alzheimers: Enigmatic Conclusions from Science **13**

**Chapter 2 15**

**Chapter 3 35**

**Chapter 4 61**

Pharmaceutical Limits in Therapeutic Options **73**

**Chapter 5 75**

**Chapter 6 93**

*by Francisco Javier Garzón-Maldonado and María Dolores Martinez-Valle Torres*

Introductory Chapter: Beyond Risk Alleles - Invoking Cognitive Lesions in

Fact, Fiction, or Evolution: Mechanism Hypothesis of Alzheimer's Disease

Mitochondria and Alzheimer's Disease: An Electron Microscopy Study

Putative Involvement of Thiol Protease Inhibitor in the Function of
