**Abstract**

*Cutaneous Melanoma*

1997;**121**(5):508

[16] Baergen RN, Johnson D, Moore T, Benirschke K. Maternal melanoma metastatic to the placenta: A case report and review of the literature. Archives of Pathology & Laboratory Medicine.

[17] Ignatko IV, Strizhakov AN, Protsenko DN, Afanasjeva NV, Djadykov IN, Zairatyantz GO, et al. Melanoma and pregnancy: Risks, course and prognosis. Gynecology, Obstetrics and Perinatology. 2018;**17**(1):83-87. DOI: 10.20953/1726-1678-2018-1-83-87

[18] Fedorenko IV, Paraiso KHT, Smalley KSM. Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma. Biochemical Pharmacology. 2011;**82**(3):201-209

[19] Driscoll MS, Grant-Kels JM. Hormones, nevi, and melanoma: An approach to the patient. Journal of the American Academy of Dermatology.

[20] Vorobiev AV, Makatsaria AD, Bitsadze VO, Brenner B. Dysfunction of the hemostatic system and carcinogenesis: The current state of the matter. Obstetrics and Gynecology. 2017;**8**:28-33. DOI:

[21] Chapman PB, Robert C, Larkin J, Haanen JB. Vemurafenib in patients with BRAFV600 mutation-positive metastatic melanoma: Final overall survival results of the randomized BRIM-3 study. Annals of Oncology. 2017;**28**(10):2581-2587. DOI: 10.1093/annonc/mdx339

[22] Committee Opinion No. 656. Guidelines for diagnostic imaging during pregnancy and lactation: American College of Obstetricians and Gynecologists' Committee on Obstetric Practice. Obstetrics and Gynecology.

2016;**127**(2):e75-e80

2007;**57**(6):919

10.18565/aig.2017.8.28-33

**66**

Subungual melanoma (SUM) is a subtype of acral melanoma. Its incidence in dark phototypes, Hispanics and Asians, is around 20% and accounts for 50% of acral melanomas. It is an infrequent subtype in Caucasians representing only 3%. Subungual melanoma arises from dormant melanocytes in the nail matrix and exceptionally from melanocytes in the nail bed. In its initial phases of radial growth, it presents as longitudinal melanonychia. The differential diagnoses are melanocytic activation (racial, traumatic), nail matrix nevi, and lentigos. Prognosis depends on Breslow depth at diagnosis. For in situ melanoma, treatment consists of conservative surgical removal of the nail unit with 5 mm margins.

**Keywords:** subungual melanoma, longitudinal melanonychia, acral melanoma, nail melanoma
