**3.2 Treatment strategy**

There are some complications of type 2 DM that affect the brain; it is believed that diabetes treatment may have beneficial effects on cognition. Three different trials reported that intensive glycaemic control alleviate microvascular complications but does not alleviate macrovascular complications in geriatric patients with long-duration of type 2 diabetes and high cardiovascular risk [62–64]. The intensive treatment of type 2 DM leads to hypoglycaemia which may contribute to cognitive decline and eliminate the benefits of intensive treatment [63, 65, 66]. Hypoglycaemia is more common in intensive glycaemic control than in standard glycaemic control [67].


**Table 1.**

*Cognitive domains affected by type 1 and type 2 DM (with strong supporting data).*


**Table 2.**

*Cognitive domains affected by type 1 and type 2 DM (with less supporting data).*
