*4.1.4 Regulation of SGLT1 expression*

The complex process of regulation of activity and expression of SGLT1 occurs in a tissue-specific manner. In the small intestine, upregulation of SGLT1 expression occurs in response to high-salt and/or high-glucose diet through transcriptional regulation which is also responsible for the circadian periodicity of SGLT1 expression [44, 45]. Its expression gets upregulated in the small intestine in diabetics [46] and in response to bacterial infections [35], while downregulation of SGLT1 expression occurs during chronic intestinal inflammation [47].
