**Conflicts of interest**

The author notes that he is a member of the DSMB and CEC for Medtronic Diabetes and serves on the Speaker's Bureau for Sanofi and Astra Zeneca.

## **Notes/thanks/other declarations**

The author wishes to thank his wife for assisting in the research for this chapter and his associate and staff for permitting him to devote extra time from the practice to complete this endeavor.
