**4. Chronic pancreatitis**

Pediatric chronic pancreatitis is unusual and the incidence increases with age (0.5 per 100,000 in young adults) but this condition presents a progressive behavior and is poorly responsive to therapy.

Chronic pancreatitis has been defined as a persistent inflammatory injury of the pancreas characterized by irreversible architectural changes that cause pain and/or irreversible loss of function [22].
