**Conflict of interest**

The authors declare no conflicts of interest.

*Epileptic Encephalopathies in Infants and Children DOI: http://dx.doi.org/10.5772/intechopen.85378*

*Epilepsy - Advances in Diagnosis and Therapy*

ment after focal resection [101].

**10. Conclusion**

rationale for treatment.

**Conflict of interest**

The authors declare no conflicts of interest.

of the time, a normal development until the start of language regression. Seizures of LKS often respond well to treatment with AED, but the speech and language impairments often persist, despite seizure control [100]. Occasional cases can be secondary to structural lesions such as benign temporal lobe tumors with improve-

The aim of treatment is to stop seizures and eliminate epileptic discharges in the EEG; this will prevent and reverse cognitive decline in the idiopathic group and will prevent any further deterioration predetermined by the underlying pathology [18]. For it, early diagnosis and rapid appropriate and effective treatment are required. Seizures in LKS are easier to control than seizures in CSWS. Many old and new AEDs are effective, depending on the seizure types. Valproate, sulthiame, benzodiazepines, ethosuximide, levetiracetam, lamotrigine, intravenous immunoglobulin (IVIG), corticosteroids, and ketogenic diet could be effective. The sodium channelblocking AEDs are contraindicated [17]. In some cases, with severe linguistic

Epileptic encephalopathy is defined as a condition where the epileptic activity itself may contribute to the severe neurological and cognitive impairment seen, over and above that would be expected from the underlying pathology alone. The epilepsy syndromes at high risk of this are a disparate group of conditions characterized by epileptic seizures that are difficult to treat and developmental delay. Knowledge of the various severe epilepsy syndromes is vital to understanding the

**9.5 Treatment of encephalopathies with CSWS, including LKS**

impairment, subpial intracortical transections have been successful.

**98**
