Author details

Alexey Kholin

the literature, this form is also known as Markand-Blume-Ohtahara syndrome [37]. Unlike MMPSI, this form manifests with predominantly pseudogeneralized seizures: bilateral axial tonic spasms, atypical absences, and myoclonic but focal seizures could also observed. But SE-MISF and MMPSI could have evolutional

Therefore, malignant migrating partial seizures of infancy is the third type of

suppression-burst pattern (Aicardi and Ohtahara syndromes) and West syndrome, when the cerebral cortex is more prone to generate epileptic excitation migrating from one area of the cortex to another, without clear interregional organization. This condition is caused by age-dependent features of infant brain with cortex

The definition of this syndrome has not been defined in the international classi-

I would like to express my special thanks to a veteran of World War II, the world's famous coryphaeus of neurology and epileptology, Academician and Professor Vladimir Alexeevich Karlov; to an expert in epilepsy, President of the scientific council of the French Epilepsy Research Foundation, leading specialist of Children's Hospital Necker, Professor Olivier Dulac; to my German teacher and mentor, Professor Hans Holthausen; to my scientific supervisors and epilepsy experts, Professor Konstantin Yurievich Mukhin and Professor Andrey Sergeevich Petrukhin; to the Head of the Department of Neurology, Neurosurgery and Medical Genetics of Pirogov Russian National Research Medical University, Professor Nikolay Nikolaevich Zavadenko; to the Head of the Department of Psychoneurology N2 of the Russian Children Clinical Hospital, Dr. Elena Stepanovna Il'ina; and to all my colleagues. Also, I would like to extend my special thanks to my big family and especially my wife Elena!

fication of epilepsies and epileptic syndromes. The term "malignant migrating partial seizures of infancy" characterizes this form of epilepsy rather as syndrome, so it is proposed to discuss the following title "malignant epilepsy of infancy with migrating multifocal seizures" that may more fully capture the essence of the disease. Taking into account contributions of scientists that first described this form of epilepsy (Coppola) and gave the most detailed description of the clinical and neurophysiological criteria (Dulac), the following definition is proposed: Coppola-

infantile epileptic encephalopathy, along with early encephalopathies with

hyperexcitability at a certain stage of evolution [3, 38].

changes into each other.

Epilepsy - Advances in Diagnosis and Therapy

Dulac syndrome [39].

Acknowledgements

Conflict of interest

126

No conflict of interest.

Department of Neurology, Neurosurgery and Medical Genetics of Pediatric Faculty, Pirogov Russian National Research Medical University, Moscow, Russia

\*Address all correspondence to: drkholin@mail.ru

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