**Conflict of interest**

The studies of the combination of released-active form of antibodies to S100 protein and released-active form of antibodies to endothelial NO synthase, mentioned in this review, were funded by a grant from OOO "NPF 'MATERIA MEDICA HOLDING'." Fateeva V.V., Nikulina K.V., Khacheva K.K., Khakimova G.R. and Epstein O.I. are employees and a founder of the OOO "NPF 'MATERIA MEDICA HOLDING'," respectively. Divaza is a preparation manufactured and marked by OOO "NPF 'MATERIA MEDICA HOLDING'." Patents on Divaza belong to Epstein O.I. Vorob'eva O.V. received an investigator grant from OOO "NPF 'MATERIA MEDICA HOLDING'" to conduct the clinical trials of Divaza, mentioned in this review.

#### **Abbreviations**

