**Abstract**

The authors present an analysis of current research and their own data on the link between endothelial dysfunction (ED) and the severity of depression in middle-aged patients with cerebral microangiopathy. Levels of peripheral inflammatory and endothelial dysfunction markers were measured using the enzymelinked immunosorbent assay (ELISA). The results of the comparative and correlation analyses showed a statistically significant correlation between the severity of depression and increased levels of inflammatory, as well as endothelial dysfunction

**Keywords:** inflammatory marker, endothelial dysfunction maker, depression, cerebral microangiopathy, Divaza
