**3. Conclusions**

Epidemiologic observations have demonstrated that prepregnant obese women with underlying mechanisms of metabolic syndrome are at increased risk of pregnancy-related adverse outcomes of VTE, HDP, and GDM. Above all, maternal death by pregnancy-related VTE has an impact of great magnitude in the childbearing population. The mechanisms underlying the pathogenesis of VTE remain poorly understood although the overlapping connections among obesity, high estrogen levels, and prothrombotic status are essential keys for expanding knowledge.

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**Author details**

Motoi Sugimura

*Metabolic Syndrome and Pathogenesis of Obesity-Related Adverse Outcomes in Pregnancy*

Department of Obstetrics, Gynecology and Family Medicine, Hamamatsu

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

University School of Medicine, Hamamatsu, Japan

provided the original work is properly cited.

\*Address all correspondence to: msugimu@hama-med.ac.jp

*DOI: http://dx.doi.org/10.5772/intechopen.93144*
