**Abstract**

Malarial systemic pathophysiology refers to physiological changes or abnormalities that are experienced by individuals infected with the *Plasmodium* parasite not be presenting in the absence of active, chronic or previous infection. The pathologies are derived, in part, from OS induced insults whose mediators are readily available in malaria. The malaria disease is equivalent to the pathophysiology as shown by the abnormal syndromic expressions ranging from ailments that affect homeostatic mechanisms and processes to tissues and organ specific damages and derangements. Phytotherapeutic remedies refer to the natural phytochemicals or plant medicinal compounds and their derivatives with known antiparasitic and antimalarial disease effects in both experimental and clinical situations. The chapter explores how *Plasmodium* infection generates or cause to be generated oxidative stress, how oxidative stress drives systemic disease process and how phytotherapeutics treatment (artemisinins) and administration (asiatic acid) in malaria resolves the various pathologies as a current situational analysis.

**Keywords:** malaria, phytochemicals, phytotherapeutics, asiatic acid, artemisinin, severe malaria anemia, *Plasmodium falciparum*, oxidative stress, reactive oxygen species, anti-disease
