**Author details**

Ettore Bergamini1,2\* and Gabriella Cavallini3

1 University Campus Biomedico, Roma, Italy

2 Volterra Ricerche Onlus Foundation, Volterra, Italy

3 Interdepartmental Research Centre on Biology and Pathology of Aging, University of Pisa, Italy

\*Address all correspondence to: ettore.bergamini@gmail.com

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**29**

*Primary Prevention of Alzheimer's Disease (AD) DOI: http://dx.doi.org/10.5772/intechopen.85418*

> [8] Stevens A, Lowe J, Scott I. Core Pathology. 3rd ed. Edinburgh: Mosby

[9] Bergamini E, Bizzarri R, Cavallini G, Cerbai B, Chiellini E, Donati A, et al. Ageing and oxidative stress: A role for dolichol in the antioxidant machinery of cell membranes? Journal of Alzheimer's Disease. 2004;**6**:129-135. DOI: 10.3233/

[10] Xue-Shan Z, Juan P, Qi W, Zhong R, Li-Hong P, Zhi-Han T, et al.

Imbalanced cholesterol metabolism in Alzheimer's disease. Clinica Chimica Acta. 2016;**456**:107-114. DOI: 10.1016/j.

[11] Cheng H, Vetrivel KS, Gong P, Meckler X, Parent A, Thinakaran G. Mechanisms of disease: New therapeutic strategies for Alzheimer's disease-targeting APP processing in lipid rafts. Nature Clinical Practice.

Neurology. 2007;**3**:374-382

[12] Wang HL, Wang YY, Liu XG, Kuo SH, Liu N, Song QY, et al. Cholesterol, 24-hydroxycholesterol, and 27-hydroxycholesterol as surrogate biomarkers in cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease: A meta-analysis. Journal of Alzheimer's Disease.

2016;**51**:45-55. DOI: 10.3233/JAD-150734

Gustafson D, Schröder J, Schönknecht P. Cholesterol in mild cognitive

impairment and Alzheimer's disease in a birth cohort over 14 years. European Archives of Psychiatry and Clinical Neuroscience. 2014;**264**:485-492. DOI:

[13] Toro P, Degen C, Pierer M,

10.1007/s00406-013-0468-2

[14] Devassy JG, Leng S, Gabbs M, Monirujjaman M, Aukema HM. Omega-3 polyunsaturated fatty acids and oxylipins in neuroinflammation and management of Alzheimer disease.

Elsevier; 2009

JAD-2004-6204

cca.2016.02.024

[1] Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American Journal of Pathology. 2012;**181**:1426-1435. DOI: 10.1016/j.

**References**

ajpath.2012.06.033

cub.2012.07.024

[2] Niccoli T, Partridge L. Ageing as a risk factor for disease. Current Biology. 2012;**22**:R741-R752. DOI: 10.1016/j.

[3] Chen H, Kwong JC, Copes R, Tu K, Villeneuve PJ, van Donkelaar A, et al. Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: A population-based cohort study. Lancet.

2017;**389**:718-726. DOI: 10.1016/

[4] Singhrao SK, Harding A, Poole S, Kesavalu L, Crean S. Porphyromonas gingivalis periodontal infection and its putative links with

Alzheimer's disease. Mediators of Inflammation. 2015;**2015**:137357. DOI:

[5] Davies KJ. The oxygen paradox, oxidative stress, and ageing. Archives of Biochemistry and Biophysics. 2016;**595**:28-32. DOI: 10.1016/j.

[6] Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, et al. The oxygen paradox, the French paradox, and age-related diseases. Geroscience. 2017;**39**:499-550. DOI: 10.1007/

[7] Ames BN, Shigenaga MK. Oxidants are a major contributor to aging. Annals of the New York Academy of Sciences. 1992;**663**:85-96. DOI: 10.1111/j.1749-

S0140-6736(16)32399-6

10.1155/2015/137357

abb.2015.11.015

s11357-017-0002-y

6632.1992.tb38652.x

*Primary Prevention of Alzheimer's Disease (AD) DOI: http://dx.doi.org/10.5772/intechopen.85418*
