**Author details**

Troy D. Wood1 \*, Amber Flynn Charlebois2 , Emily R. Sekera1 , Christopher L. Pennington3 , Heather L. Rudolph4 , Yong Seok Choi<sup>5</sup> and Giuseppe Fanciulli6

1 Department of Chemistry, University at Buffalo, Buffalo, NY, United States

2 Department of Chemistry, Nazareth College, Rochester, NY, United States

3 Shared Equipment Authority, Rice University, Houston, TX, United States

4 Thermo Fisher Scientific, Grand Island, NY, United States

5 College of Pharmacy, Dankook University, Cheonon, Chungnam, Republic of Korea

6 Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Sardinia, Italy

\*Address all correspondence to: twood@buffalo.edu

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Stercobilin: A Putative Link between Autism and Gastrointestinal Distress?*

et al. The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS One.

[10] Bresnahan M, Hornig M, Schultz AF, Gunnes N, Hirtz D, Lie KK, et al. Association of maternal report of infant and toddler gastrointestinal symptoms with autism: Evidence from a prospective birth cohort. JAMA Psychiatry. 2015;**72**(5):466-474

[11] Rhee SH, Pothoulakis C, Mayer EA. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nature Reviews. Gastroenterology & Hepatology. 2009;**6**(5):306-314

[12] Sherwin E, Sandhu KV, Dinan TG, Cryan JF. May the force be with you: The light and dark sides of the microbiotagut-brain axis in neuropsychiatry. CNS

[13] Cryan JF, Dinan TG. Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews. Neuroscience.

[14] Rogers GB, Keating DJ, Young RL, Wong ML, Licinio J, Wesselingh S. From gut dysbiosis to altered brain function and mental illness: Mechanisms and pathways. Molecular Psychiatry.

[15] Panksepp J. A neurochemical theory of autism. Trends in Neurosciences.

[16] Whiteley P, Shattock P, Knivsberg AM, Seim A, Reichelt KL, Todd L, et al. Gluten- and casein-free dietary intervention for autism spectrum conditions. Frontiers in Human Neuroscience. 2012;**6**:344

[17] Whiteley P, Rodgers J, Savery D, Shattock P. A gluten-free diet as an

Drugs. 2016;**30**(11):1019-1041

2012;**13**(10):701-712

2016;**21**(6):738-748

1979;**2**:174-177

2012;**7**(4):e33224

*DOI: http://dx.doi.org/10.5772/intechopen.84791*

infantile autism, 1943-1955. Psychiatric research reports of the American Psychiatric Association. 1957;**7**:55-65

[1] Kanner L, Eisenberg L. Early

[2] Association AP. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association; 2013

[3] Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, et al. Prevalence of autism spectrum disorder among children aged 8 years— Autism and developmental disabilities monitoring network, 11 sites, United States, 2014. MMWR Surveillance Summaries. 2018;**67**(6):1-23

[4] Ospina MB, Krebs Seida J, Clark B, Karkhaneh M, Hartling L, Tjosvold L, et al. Behavioural and developmental interventions for autism spectrum disorder: A clinical systematic review.

PLoS One. 2008;**3**(11):e3755

2005;**34**(3):523-540

2013;**1**(1):1-11

2010;**7**(3):320-327

[5] Ozonoff S, Goodlin-Jones BL, Solomon M. Evidence-based assessment of autism spectrum disorders in children and adolescents. Journal of Clinical Child and Adolescent Psychology.

[6] Herbert MR, Russo JP, Yang S, Roohi J, Blaxill M, Kahler SG, et al. Autism and environmental genomics. Neurotoxicology. 2006;**27**(5):671-684

[7] Rudolph HL, Friesen WL, Wood TD. The hunt for biomarkers of autism spectrum disorders. Journal of Metabolomics & Systems Biology.

[8] Bauman ML. Medical comorbidities in autism: Challenges to diagnosis and treatment. Neurotherapeutics.

[9] Kohane IS, McMurry A, Weber G, MacFadden D, Rappaport L, Kunkel L,

**References**

*Stercobilin: A Putative Link between Autism and Gastrointestinal Distress? DOI: http://dx.doi.org/10.5772/intechopen.84791*
