Meet the editor

Kenjiro Fukao, MD, Ph.D. graduated from Kyoto University School of Medicine and majored in psychiatry. Then he specialized in psychiatric epileptology, working in the National Epilepsy Center in Shizuoka, Japan, University Hospital of Zürich, Switzerland and Kyoto University Hospital. He subsequently specialized in psychiatric epileptology, working at the National Epilepsy Center, Shizuoka, Japan, and the University Hospital of

Zürich, Switzerland. He obtained a Ph.D. with research on the magnetoencephalographic study of patients with epileptic psychosis. He trained in phenomenological psychopathology with anthropological psychiatrist Prof. Kimura Bin. Currently, Dr. Fukao is a professor in the Department of Psychology, Faculty of Human Sciences, Tezukayama Gakuin University, Japan.

Contents

**Section 1**

**Section 2**

**Section 3**

*and Rym Rafrafi*

Understanding / Psychosis

The Axiological Structure in Psychosis

*István Laszlovszky and György Németh*

*by Francisco Martín-Murcia and Adolfo J. Cangas*

Clinical Staging in Schizophrenia Spectrum Disorders *by Zsófia Borbála Dombi, Ágota Barabássy, Barbara Sebe,* 

The Many Faces of Negative Symptoms in Schizophrenia *by Mihaela Fadgyas Stanculete and Octavia Capatina*

Role of Immunity in Pathogenesis of Psychosis

The Role of Epigenetics in Psychosis *by Esmaeil Shahsavand Ananloo*

*by Wafa Abdelghaffar, Oussama Sidhom, Lilia Laadhar* 

DNA Methyltransferases and Schizophrenia: Current Status

*by Pranay Amruth Maroju and Kommu Naga Mohan*

*by Kenjiro Fukao*

**Preface XI**

Phenomenology **1**

**Chapter 1 3**

**Chapter 2 9**

Psychopathology **19**

**Chapter 3 21**

**Chapter 4 39**

Pathophysiology **59**

**Chapter 5 61**

**Chapter 6 77**

**Chapter 7 97**

## Contents


Preface

Psychosis has historically been the central problem of psychiatry because it harms both reason and emotion, even sometimes personality itself, and, whether rapidly or gradually, destroys the productive life of people. It is also intriguing for researchers due to the variety of subjective symptoms, which are enigmatic and provoke artistic imaginations.

Schizophrenia, the representative syndrome of psychotic disorders, still remains the hardest subject for psychiatric practice, although recently said to be becoming milder in the clinical features. Pathogenesis of schizophrenia is not yet solved and thus antipsy-

This volume presents current research for the elucidation of psychosis in three different aspects: phenomenological, which relates to the philosophical or conceptual basis of psychosis; psychopathological, which relates to clinical manifestations of psychosis; and pathophysiological, which relates to the scientific pursuit for the mechanism of psychosis.

Chapter 1, "Understanding / Psychosis," deals with the very basis of diagnosis of psychosis differentiated from neurosis or psychogenic symptoms, namely, un-understandability

Chapter 2, "The Axiological Structure in Psychosis," presents the phenomenological-

Chapter 3, "Clinical Staging in Schizophrenia Spectrum Disorders," summarizes the state-of-the-art knowledge of clinical staging in schizophrenia spectrum disorders.

Chapter 5, "Role of Immunity in Pathogenesis of Psychosis," reviews the immune-

inflammatory theory of schizophrenia and its clinical implications.

epigenetic dysregulation in the pathogenesis of schizophrenia.

the dysregulation of DNA methyltransferases in schizophrenia.

Chapter 4, "The Many Faces of Negative Symptoms in Schizophrenia," addresses recent advances regarding the concepts, definitions, and classifications of negative symptoms

Chapter 6, "The Role of Epigenetics in Psychosis," deals with the possible significance of

Finally, Chapter 7, "DNA Methyltransferases and Schizophrenia: Current Status," reviews

**Kenjiro Fukao, M.D., Ph.D.** Tezukayama Gakuin University,

Osaka, Japan

This book provides readers with novel insight into psychosis and will help to advance

existential analysis of psychosis and suggests its therapeutic implications.

chotic medications are not curative but rather symptomatic therapies.

as the impossibility of understanding in Japers' sense.

of schizophrenia and their etiological model.

research in the field.
