**11. Clinical applications**

There is a big range of applications of the AI and CAD in various fields of medicine. These applications have received a premarket approval (PMA). This encompasses the devices which have been shown to pose serious levels of risk for the users. In these cases the FDA guidelines recommend newer devices could be safer and more effective in the near future.

In the last decade there has been a considerable increase in their accuracy as systems for diagnostic help [25, 26]. The AI systems in mammography have been successful in detecting differences between the mass lesions and micro-calcifications [42]. For micro-calcifications it has shown that the AI systems show high performance and sensitivity which is greatly used by doctors in making an educated decision during diagnosis making. The data from multiple views and combination of different modalities like ultrasonography (US), magnetic resonance (MR) imaging, and digital breast tomosynthesis have shown to be really promising in enhancing the diagnosis and enriching the data for future diagnoses [34].
