**7. Conclusions**

Most of the skin diseases involve any defects in the skin due to its interaction with UV irradiation, pollutant, and/or other internal and external factors. Because of that, several skin diseases such as pigmentation disorders (melasma and vitiligo), cutaneous leishmaniasis, rashes (acne vulgaris, seborrheic dermatitis and dandruff, psoriasis, and atopic dermatitis), and rosacea have been reported and investigated for better medical treatment. Chalcones, a group of privileged molecules with 1,3-diaryl-2-propen-1-one backbone, exhibit high efficacy in treating those skin diseases. These efficacies are strongly related to the good activity of chalcones as antioxidant, anti-inflammation and immunomodulation, anti-angiogenesis, antimicrobial agents, as well as their ability in modulating various enzymes. Even though chalcones are really potential to be used as a photoprotective agent, the utilization of designed synthetic chalcones is still limited due to their low photostability and medium to high toxicity and also because of unknown protein targets of those skin diseases as for today reports. Development in these fields is still required to obtain more potent drugs with excellent biocompatibility and other desired properties.
