**Abstract**

Diabetes is one of the most important chronic diseases that impact human health, and the total number of diabetes patients worldwide may rise to about 370 million in 2030 (170 million in 2000). Type 2 diabetes patients account for 90% of all diabetes worldwide. Previous literature reported that type 2 diabetes patients have lower quality of life (QoL) than those healthy persons and that a sedentary lifestyle is a modifiable risk factor for type 2 diabetes and an independent predictor of poor quality of life. When the physical activity is planned, structured, and repetitive bodily movement performed to improve or maintain one or more components of physical fitness, it is a denominated physical exercise. Physical exercise has been effective by altering the body composition, glycemic control, blood pressure, insulin resistance, and mental and physical components of QoL. In this chapter, we also focus our attention on mental disorders. Depression and anxiety are the most common in those patients, which can lead to unfavorable influences on metabolic control and micro- and macrovascular complications compared to those with diabetes alone.

**Keywords:** type 2 diabetes, quality of life, physical exercise, anxiety, depression
