**5.2 Evidence-based medicine: definitions and impact on medical practice**

The introduction of evidence-based medicine 40–50 years ago had a great impact on medical practice almost everywhere. That concept became very popular in a very short time. The main reason being that it offers a strong foundation for the justification of decision-making in the course of management of clinical cases. The evidence-based medicine was defined by El Kayaly et al. as "Evidence-based clinical medicine can be seen as the conscious incorporation of the best evidence that is currently available into daily clinical practice covering prevention, diagnostics, clinical assessments, treatments and patient-centered care" [10]. The implementation of the concept of EBM is significantly helpful and challenging for many practitioners for several reasons such as:

