**3.8 Mechanical downsizing of a gadolinium(III)-based metal: organic framework for anticancer drug delivery**

A Gd(III)-based permeable metal–natural system (MOF), Gd-pDBI, has been blended utilizing fluorescent linker pDBI (pDBI = (1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), bringing about a three-dimensional interpenetrated structure with an one-dimensional open channel (1.9 × 1.2 nm) loaded up with hydrogen-bonded water gatherings. Gd-pDBI shows high warm steadiness, porosity, amazing water solidness, alongside organic-solvent and mellow corrosive and base soundness with maintenance of crystallinity. Gd-pDBI was changed to the nanoscale system (ca. 140 nm) by mechanical pounding to yield MG-Gd-pDBI with phenomenal water dispersibility (>90 min), keeping up its porosity and crystallinity. In vitro and in vivo investigations on MG-Gd-pDBI uncovered its low blood poisonous quality and most noteworthy medication stacking (12 wt%) of anticancer medication doxorubicin in MOFs answered to date with pH-responsive cancer-cell-specific medication discharge [22].
