**Chapter 5**

*Rare Earth Elements and Their Minerals*

[45] Radbruch A, Weberling LD, Kieslich PJ, Hepp J, Kickingereder P, Wick W, et al. High-signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: Evaluation of the macrocyclic gadolinium-based contrast agent gadobutrol. Investigative Radiology. 2015;**50**:805-810. DOI: 10.1097/ RLI.0000000000000227

[51] Eide PK, Ringstad G. MRI with intrathecal MRI gadolinium contrast medium administration: A possible method to assess glymphatic function in human brain. Acta Radiologica Short Reports. 2015;**4**:205846011560963. DOI:

10.1177/2058460115609635

[52] Naganawa S, Nakane T,

mp.2016-0039

Kawai H, Taoka T. Gd-based contrast enhancement of the perivascular spaces in the basal ganglia. Magnetic Resonance in Medical Sciences. 2017;**16**:61-65. DOI: 10.2463/mrms.

[46] McDonald RJ, McDonald JS, Kallmes DF, Jentoft ME, Murray DL, Thielen KR, et al. Intracranial gadolinium deposition after contrast-enhanced MR imaging. Radiology. 2015;**275**:772-782.

DOI: 10.1148/radiol.15150025

Radiology. 2014;**49**:685-690

[48] Khairinisa MA, Takatsuru Y, Amano I, Erdene K, Nakajima T, Kameo S, et al. The effect of perinatal gadolinium-based contrast agents on adult mice behavior. Investigative Radiology. 2018;**53**:110-118. DOI: 10.1097/RLI.0000000000000417

[49] Erdene K, Nakajima T, Kameo S, Khairinisa MA, Lamid-Ochir O, Tumenjargal A, et al. Organ retention of gadolinium in mother and pup mice: Effect of pregnancy and type of gadolinium-based contrast agents. Japanese Journal of Radiology. 2017;**35**:568-573. DOI: 10.1007/

s11604-017-0667-2

10.1172/JCI67677

[50] Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, et al. Brainwide pathway for waste clearance captured by contrast-enhanced MRI. The Journal of Clinical

Investigation. 2013;**123**:1299-1309. DOI:

[47] Errante Y, Cirimele V, Mallio CA, Di Lazzaro V, Zobel BB, Quattrocchi CC. Ovid progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients. Investigative

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