**Abstract**

We envisage a world where genetic engineering, artificial intelligence (AI), and quantum computing (QC) will coalesce to bring about a forced speciation of the *Homo sapiens*. A forced speciation will drastically reduce the emergence time for a new species to a few years compared to Nature's hundreds of millennia. In this chapter, we explain the basic concepts that would allow a forced speciation of the *Homo sapiens* to occur and its consequences on life on Earth thereafter. Accelerating speciation mediated by *Homo sapiens* via domestication, gene splicing, and gene drive mechanisms is now scientifically well understood. Synthetic biology can advance speciation far more rapidly using a combination of clustered regularly interspaced short palindromic repeats (CRISPR) technology, advanced computing technologies, and knowledge creation using AI. The day is perhaps not far off when *Homo sapiens* itself will initiate its own speciation once it advances synthetic biology to a level where it can safely modify the brain to temper emotion and enhance rational thinking as a means of competing against AI-embedded machines guided by quantum algorithms.

**Keywords:** synthetic biology, artificial intelligence, quantum computing, information theory, genetic engineering
