**Author details**

Afiah Nasuha Aznan and Zakiah Jubri\* Department of Biochemistry, Faculty of Medicine Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

\*Address all correspondence to: zakiah.jubri@ppukm.ukm.edu.my

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**115**

*Silencing of Peroxiredoxin-4 in Anticancer Activity of Gamma-Tocotrienol*

Medicine. 2015;**15**(1):1. DOI: 10.1186/

antiproliferative effect of palm oil gamma-tocotrienol on isoprenoid pathway of hepatoma cell line.

European Journal of Scientific Research.

[9] Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Letters. 2005;**229**(2):181-191. DOI: 10.1016/j.

s12906-015-0590-y

2005;**18**(4):576-583

canlet.2005.06.036

mam.2007.03.001

[10] Sen CK, Khanna S, Roy S.

[11] Ahsan H, Ahad A, Iqbal J,

10.1186/1743-7075-11-52

10.1007/s12263-011-0234-x

phymed.2017.03.004

[14] Bachawal SV, Wali VB,

Tocotrienols in health and disease: The other half of the natural vitamin E family. Molecular Aspects of Medicine. 2007;**28**(5):692-728. DOI: 10.1016/j.

Siddiqui WA. Pharmacological potential of tocotrienols: A review. Nutrition and Metabolism. 2014;**11**(1):52. DOI:

[12] Aggarwal B, Nesaretnam K. Vitamin E tocotrienols: Life beyond tocopherols. Genes and Nutrition. 2012;**7**(1):1. DOI:

[13] Abubakar IB, Lim K-H, Kam T-S, Loh H-S. Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A. Phytomedicine. 2017;**30**:74-84. DOI: 10.1016/j.

Sylvester PW. Combined γ-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. Anticancer Research. 2010;**30**(2):429-437

[8] Zakiah J, WZ WN. The

*DOI: http://dx.doi.org/10.5772/intechopen.88813*

[1] Fujii J, Ikeda Y. Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Report. 2002;**7**(3):123- 130. DOI: 10.1179/135100002125000352

[2] Sato Y, Kojima R, Okumura M, Hagiwara M, Masui S, Maegawa K-I, et al. Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding. Scientific Reports. 2013;**3**:1-13. DOI:

[3] Zhu L, Yang K, Wang X, Wang C-C. A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. PLoS One. 2014;**9**(8):e105529. DOI: 10.1371/

[4] Hwang K-E, Park D-S, Kim Y-S, Kim B-R, Park S-N, Lee M-K, et al. Prx1 modulates the chemosensitivity of lung cancer to docetaxel through suppression

of FOXO1-induced apoptosis. International Journal of Oncology. 2013;**43**(1):72-78. DOI: 10.3892/

[5] Schulte J. Peroxiredoxin 4: A multifunctional biomarker worthy of further exploration. BMC Medicine. 2011;**9**(1):137. DOI: 10.1186/1741-7015-9-137

[6] Yi NAN, Xiao MB, Ni WK, Jiang F, Lu CH, Ni R-Z. High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. Molecular and Clinical Oncology.

2014;**2**(5):767-772. DOI: 10.3892/

[7] Sazli FAR, Jubri Z, Rahman MA, Karsani SA, Top AGM, Ngah WZW. Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line. BMC Complementary and Alternative

**References**

10.1038/srep02456

journal.pone.0105529

ijo.2013.1918

mco.2014.317

*Silencing of Peroxiredoxin-4 in Anticancer Activity of Gamma-Tocotrienol DOI: http://dx.doi.org/10.5772/intechopen.88813*
