**Chapter 7**

*Synthetic Biology - New Interdisciplinary Science*

[75] Birringer M, Lington D, Vertuani S, Manfredini S, Scharlau D, Glei M, et al. Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress. Free Radical Biology & Medicine. 2010;**49**:1315-1322. DOI: 10.1016/j. freeradbiomed.2010.07.024

[76] Yedjou CG, Tchounwou HM, Tchounwou PB. DNA Damage, Cell Cycle Arrest, and Apoptosis Induction Caused by Lead in Human Leukemia Cells. International Journal Environmental Research Public Health. 2015;**22**(13):1660-1672. DOI: 10.3390/

[77] Argüelles S, Camandola S, Cutler RG, Ayala A, Mattson MP. Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions. Free Radical Biology & Medicine. 2014;**67**:131-138. DOI: 10.1016/j.freeradbiomed.2013.10.015

[78] Kupsco A, Schlenk D. Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. International Review of Cell and Molecular Biology. 2015;**317**:1-66. DOI:

[79] Kumari S, Badana AK, G MM, G S, Malla R. Reactive oxygen species: A key constituent in cancer survival. Biomarker Insights. 2018;**13**:35-42. DOI:

H-O. Mitogen-activated protein kinases and reactive oxygen species: How can ROS activate MAPK pathways? Journal of Signal Transduction. 2011;**2011**:6.

10.1016/bs.ircmb.2015.02.002

10.1177/1177271918755391

DOI: 10.1155/2011/792639

[80] Son Y, Cheong Y-K, Kim N-H, Chung H-T, Kang DG, Pae

ijerph13010056

**120**
