**Abstract**

Wastewater reuse has been considered as an alternative way of overcoming water scarcity in many parts of the world. However, exposures to wastewater are associated with higher prevalence of soil-transmitted helminths (STHs). Globally, about two billion people are infected with at least one species of STHs with those having heavy infections presenting considerable morbidities. The most serious STH species infecting humans include roundworm (*Ascaris lumbricoides*), whipworm (*Trichuris trichiura*), and hookworms (*Necator americanus* and *Ancylostoma duodenale*). Despite ongoing control campaigns using preventive chemotherapy, wastewater in endemic countries still contains concentrations of STH eggs that put exposed populations at risk of infection. According to the World Health Organization, we can achieve sustainable control of STH by using improved sanitation systems. Since natural wastewater treatment systems (waste stabilization ponds and constructed wetlands) require low maintenance and operational costs, have low mechanical technology and energy consumption, they are ideal for sustainable sanitation services. In addition, natural wastewater treatment systems are reported to efficiently remove various pathogenic organisms from wastewater. This chapter explains the role of natural wastewater treatment systems as sustainable sanitation facilities in removing STH from wastewater and therefore preventing disease transmission.

**Keywords:** *Ascaris lumbricoides*, constructed wetlands, hookworms, soil-transmitted helminths, *Trichuris trichiura*, wastewater reuse, waste stabilization ponds
