**4. Experimental data**

### **4.1 Synthesis of 1-(4-nitrobenzyl)-4-phenyl-1H-1,2,3-triazole**

P-Nitrobenzyl bromide 0.216 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) and phenyl acetelyne 0.112 g (1.1 mmol) were suspended in polyethylene glycol-400 (5 mL). To this reaction mixture in copper iodide (10 mol%) was added and the reaction mixture was stirred for 10 min at 25°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to yield the desired product.

MF/FWt: C15H12O2N4/280.10, MP: 198–200°C.

IR (cm<sup>−</sup><sup>1</sup> ): 3001, 2988, 2829, 1613, 1209, 876.

1 H NMR (300 MHz, CDCl3, δ ppm): 8.13–8.15 (d,2H), 7.08–7.10 (d,2H),7.80–7.82 (d,2H), 6.85–6.87 (d,2H), 7.10–7.12 (s,1H), 8.39 (s,1H, triazole), 4.73 (s,2H).

**59**

IR (cm<sup>−</sup><sup>1</sup>

IR (cm<sup>−</sup><sup>1</sup>

1

1

*PEG-Mediated Green One Pot Synthesis by Using Click Chemistry*

**4.2 Synthesis of 1-(4-nitrobenzyl)-4-p-tolyl-1H-1,2,3-triazole**

P-Nitrobenzyl bromide 0.216 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) and 1-ethynyl-4-methylbenzene 0.127 g (1.1 mmol) were suspended in polyethylene glycol-400 (5 mL). To this reaction mixture in copper iodide (10 mol%) was added and the reaction mixture was stirred for 15 min at 30°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to yield the desired product.

H NMR (300 MHz, CDCl3, δ ppm): 8.13–8.15 (d,2H), 7.08–7.10 (d,2H), 7.80–7.82

P-Nitrobenzyl bromide 0.216 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) was suspended in polyethylene glycol-400 (5 mL). The reaction mixture was stirred for 10 min at 25°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product

H NMR (300 MHz, CDCl3, δ ppm): 8.13–8.15 (d,2H), 7.08–7.10 (d,2H), (s,1H,

Benzyl bromide 0.171 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) and phenyl acetylene 0.112 g (1.1 mmol) were suspended in polyethylene glycol-400 (5 mL).

Yield: 87%, MF/FWt: C16H14N4O2/294.11, MP: 190–192°C.

): 3123, 2958, 1588, 1430, 1265, 1233, 797.

was recrystallized from ethanol to yield the desired product. Yield: 72%, MF/FWt: C10H10N4O3/234.08, MP: 134–136°C.

triazole), 4.73 (s,2H), 4.70 (s,2H), 3.65 (s,1H).

**4.4 Synthesis of 1-benzyl-4-phenyl-1H-1,2,3-triazole**

): 3643, 2950, 1609, 1508, 1430, 1265, 1233, 867.

(d,2H), 6.85–6.87 (d,2H), 8.39 (s,1H, triazole), 4.73 (s,2H), 2.56 (s,3H).

**4.3 Synthesis of (1-(4-nitrobenzyl)-1H-1,2,3-triazole-4-yl) methanol**

*DOI: http://dx.doi.org/10.5772/intechopen.83776*

*Green Chemistry Applications*

**2. Materials and method**

FTIR spectrometer in KBr pallets.

**for compounds (111)**

**4. Experimental data**

yield the desired product.

IR (cm<sup>−</sup><sup>1</sup>

1

and non-volatility of this PEG-400 solvent [23].

Melting points were recorded in open capillaries.1

availability, recyclable, easily degradable, having low toxicity, thermally stability

All chemicals were purchased from Merck and Aldrich and used as received.

Bio-Spin spectrometer at 400 MHz using TMS as an internal standard (in CDCl3). Mass spectra ESIMS were recorded and IR spectra were recorded on a Shimadzu

**3. General procedure for the synthesis of 1,4-disubstituted 1,2,3-triazole** 

Substituted organic halides (1.0 equiv), sodium azide (1.4 equiv) and substituted alkynes (1.104 equiv) were suspended in polyethylene glycol-400 (5 mL). To this copper iodide (10 mol%) was added and the re action mixture was stirred for 10–45 min at 25–35°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude

P-Nitrobenzyl bromide 0.216 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol)

glycol-400 (5 mL). To this reaction mixture in copper iodide (10 mol%) was added and the reaction mixture was stirred for 10 min at 25°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to

H NMR (300 MHz, CDCl3, δ ppm): 8.13–8.15 (d,2H), 7.08–7.10 (d,2H),7.80–7.82

and phenyl acetelyne 0.112 g (1.1 mmol) were suspended in polyethylene

(d,2H), 6.85–6.87 (d,2H), 7.10–7.12 (s,1H), 8.39 (s,1H, triazole), 4.73 (s,2H).

MF/FWt: C15H12O2N4/280.10, MP: 198–200°C.

): 3001, 2988, 2829, 1613, 1209, 876.

product was recrystallized from ethanol to yield the desired product.

**4.1 Synthesis of 1-(4-nitrobenzyl)-4-phenyl-1H-1,2,3-triazole**

H NMR were recorded on a Bruker

**58**

**4.2 Synthesis of 1-(4-nitrobenzyl)-4-p-tolyl-1H-1,2,3-triazole**

P-Nitrobenzyl bromide 0.216 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) and 1-ethynyl-4-methylbenzene 0.127 g (1.1 mmol) were suspended in polyethylene glycol-400 (5 mL). To this reaction mixture in copper iodide (10 mol%) was added and the reaction mixture was stirred for 15 min at 30°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to yield the desired product.

Yield: 87%, MF/FWt: C16H14N4O2/294.11, MP: 190–192°C.

IR (cm<sup>−</sup><sup>1</sup> ): 3123, 2958, 1588, 1430, 1265, 1233, 797.

1 H NMR (300 MHz, CDCl3, δ ppm): 8.13–8.15 (d,2H), 7.08–7.10 (d,2H), 7.80–7.82 (d,2H), 6.85–6.87 (d,2H), 8.39 (s,1H, triazole), 4.73 (s,2H), 2.56 (s,3H).
