**4.6 Synthesis of 1-4-bromobenzyl-1H-1,2,3-triazol-4-yl)methanol**

1-Bromo-4-(bromomethyl) benzene 0.249 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) were suspended in polyethylene glycol-400 (5 mL). The reaction

**61**

IR (cm<sup>−</sup><sup>1</sup>

1

*PEG-Mediated Green One Pot Synthesis by Using Click Chemistry*

mixture was stirred for 1 h at 40–45°C. Then add propargyl alcohol 0.064 g (1.1 mmol), to this reaction mixture in copper iodide (10 mol%) was added and again reaction mixture was stirred for 10–45 min at 25–35°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to

Yield: 81%, MF/FWt: C10H10BrN3O/267.00, MP: 148–150°C.

(s,1H, triazole), 5.50 (s,2H), 4.48 (s,2H), 3.50 (s,1H).

recrystallized from ethanol to yield the desired product.

Yield: 89%, MF/FWt: C17H16BrN3O/357.05, MP: 160–162°C.

): 2945, 1640, 1588, 1435, 1262, 1222, 867.

): 3660, 2950, 1643, 1578, 1435, 1262, 1222, 879.

**4.7 Synthesis of 4-benzyloxy methyl-1-4-bromobenzyl-1H-1,2,3-triazole**

H NMR (300 MHz, CDCl3, δ ppm): 7.51–7.53(d,2H), 7.14–7.16 (d,2H), 7.73

1-Bromo-4-(bromomethyl) benzene 0.249 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) and 1-bromo-4-((prop-2-ynyloxy)methyl)benzene 0.247 g (1.1 mmol) were suspended in polyethylene glycol-400 (5 mL). To this reaction mixture in copper iodide (10 mol%) was added and the reaction mixture was stirred for 10–45 min at 25–35°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was

H NMR (300 MHz, CDCl3, δ ppm): 7.49–7.51 (d,2H), 7.19–7.21 (d,2H),7.30–7.32 (d,3H), 7.44–7.46 (d,2H),7.66 (s,1H, triazole), 5.47 (s,2H), 4.53 (s,2H), 4.64 (s,2H).

*DOI: http://dx.doi.org/10.5772/intechopen.83776*

yield the desired product.

IR (cm<sup>−</sup><sup>1</sup>

1

*Green Chemistry Applications*

IR (cm<sup>−</sup><sup>1</sup>

triazole), 5.53 (s,2H).

yield the desired product.

IR (cm<sup>−</sup><sup>1</sup>

148, 149, 141.

1

1

To this reaction mixture in copper iodide (10 mol%) was added and the reaction mixture was stirred for 15 min at 30°C. after completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to yield the desired product.

H NMR (300 MHz, CDCl3, δ ppm): 6.87–6.89 (d,2H), 6.64–6.65 (t,1H), 7.12–7.13 (d,2H), 7.53–7.66 (d,2H), 7.39–7.42 (t,2H), 7.30–7.34 (t,1H), 7.66 (s,1H,

1-Bromo-4-(bromomethyl) benzene 0.249 g (1.0 mmol), sodium azide 0.091 g (1.4 mmol) and phenyl acetelyne 0.112 g (1.1 mmol) were suspended in polyethylene glycol-400 (5 mL). To this reaction mixture in copper iodide (10 mol%) was added and the reaction mixture was stirred for 20 min at 25°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to

Yield: 82%, MF/FWt: C15H13N3/235.11, MP: 139–141°C.

): 2950, 1644, 1578, 1435, 1260, 1223, 876.

**4.5 Synthesis of 1,4-bromobenzyl, 4-phenyl-1H-1,2,3-triazole**

Yield: 82%, MF/FWt: C15H12BrN3/313.02, MP: 140–142°C.

**4.6 Synthesis of 1-4-bromobenzyl-1H-1,2,3-triazol-4-yl)methanol**

H NMR (300 MHz, CDCl3, δ ppm): 8.13–8.15 (d,2H), 7.08–7.10 (d,2H), 7.80–7.82 (d,2H), 6.85–6.87 (d,2H),7.81–7.83 (t,1H), 8.39 (s,1H, triazole), 4.73 (s,2H). 13C NMR (300 MHz, CDCl3, δ ppm): 53, 113, 114, 118, 133 (carbon triazole), 159,

(1.4 mmol) were suspended in polyethylene glycol-400 (5 mL). The reaction

1-Bromo-4-(bromomethyl) benzene 0.249 g (1.0 mmol), sodium azide 0.091 g

): 2980, 1601, 1545, 1225, 1157.

**60**

mixture was stirred for 1 h at 40–45°C. Then add propargyl alcohol 0.064 g (1.1 mmol), to this reaction mixture in copper iodide (10 mol%) was added and again reaction mixture was stirred for 10–45 min at 25–35°C. After completion of the reaction (monitored by TLC), the product was extracted with EtOAc and the organic extract was dried. The crude product was recrystallized from ethanol to yield the desired product.

Yield: 81%, MF/FWt: C10H10BrN3O/267.00, MP: 148–150°C.

IR (cm<sup>−</sup><sup>1</sup> ): 3660, 2950, 1643, 1578, 1435, 1262, 1222, 879.

1 H NMR (300 MHz, CDCl3, δ ppm): 7.51–7.53(d,2H), 7.14–7.16 (d,2H), 7.73 (s,1H, triazole), 5.50 (s,2H), 4.48 (s,2H), 3.50 (s,1H).
