**4. Conclusions**

*Synthesis Methods and Crystallization*

**Figure 32.**

**Figure 33.**

*The crystal structure of complex 23.*

*One-pot synthesis of salicyloxazoline complexes.*

**Metal salts The amount of metal salts Products (%) Yield (%)** Cu(OAc)2⋅H2O 55.7 16 65 CuCl2⋅2H2O 53.2 16 85 Ni(OAc)2⋅4H2O 51.0 17 92 NiCl2⋅6H2O 53.0 17 95 CoCl2⋅6H2O 44.3 18, 20 72, 85 PdCl2 49.8 19 86 Co(OAc)2⋅4H2O 42.3 21 70 Mn(OAc)2⋅4H2O 52.6 22 80 PtCl2 33.7 23 82

*The crystal structure of complex 22.*

**40**

**Table 2.**

One-pot synthesis of oxazolinyl-zinc(II) complexes **1–23** at yields 25–95% was firstly demonstrated by assembling three-component reactions between metal salts, amino alcohols, and a variety of nitrile precursors. From the crystal structures of the complexes **1–23**, the reaction product is highly dependent on the presence of ligands, the amount of metal salts, and the nature of the substituent at the stereogenic center, giving a variety of coordination modes, such as mono- and bis-chelate complexes, mononuclear and mutinuclear complexes, etc.

Investigations into other oxazolinyl organometallic complexes and the catalytic properties of these complexes as chiral ligands are currently ongoing. These complexes exhibit bioactivities as anticancer reagents, and the future use of these complexes in medical fields is currently being developed.
