**3. Merits of phytosomes over conventional dosage forms**


**133**

*Drug Delivery through Targeted Approach with Special References to Phytosomes*

The phytosomal system is passive, non-invasive and can is suitable for immedi-

• The dose requirement is reduced due to improved absorption of the main constituent. They can also be given in smaller quantities to achieve the desired

• Low risk profile: This technology has no risk since the toxicological profiles of the phytosomal components are well documented in the scientific literature. Highly attractive market profile for products with proprietary technology. It is easy to formulate because no complicated technical investment required for the

• It enhances the absorption of lipid insoluble polar phytoconstituents through oral as well as topical route showing better bioavailability, so it has wide

• Phytosomes help to improve the absorption of active constituents and reduces

• Phosphatidylcholine used in preparation of Phytosomes, besides acting as a carrier also acts as a hepatoprotective agent. Hence produce the synergistic

• Chemical bonds are formed between phosphatidylcholine molecule and

• Application of phytoconstituents in form of phytosome improves their percutaneous absorption and act as basic carrier for transdemal drug

**5. Phospholipids: creating the structural framework for novel drug** 

These are complex substance having chemical, biochemical and nutritional characteristics by which they can distinguish as placed in a unique nutritional category. They are complex lipid molecules important for life and are found in all human and the other known structure to make cell membranes. The biochemical importance of phospholipids is reflected in their extraordinary clinical benefits as dietary supplements. The phospholipids are readily compatible with the entire range of vitamins, minerals, metabolites and herbal preparations. The dietary phospholipids and omega-3 fatty acid works in functional synergy in cell membranes. Phosphatidylcholine is a bi-functional compound miscible both in water and in oil environments, and is well absorbed when taken by mouth. Phosphatidylcholine is not merely a passive "carrier" for the bioactive compounds, but is itself a bioactive nutrient with documented clinical efficacy for liver disease (including alcoholic hepatitis). Phosphatidylcholine is present in egg yolk, brain tissue and a wide

phytoconstituent, this results better stability in Phytosome.

*DOI: http://dx.doi.org/10.5772/intechopen.86644*

ate commercialization.

therapeutic values.

production of phytosomes.

therapeutic benefits [28, 30].

• Appreciable drug entrapment.

effect to the liver targeted drug.

the dose requirements.

delivery.

**delivery systems**

**4. Pharmaceutical scope of phytosome**

• They offer a better stability profile because chemical bonds are formed between the phosphatidylcholine molecules and phytoconstituents.

The phytosomal system is passive, non-invasive and can is suitable for immediate commercialization.

