6.1.2 Manganese (Mn) II complex solid lipid nanoparticles

Transition metal complex (e.g., Manganese II complex [Mn2(μ(C6H5)2CHCOO)2(bipy)4] 2 ) has been extensively used for cancer therapy nowadays due to its potential anticancer activity (interact with the DNA). Mn(II) complex loaded SLNs were developed that showed superior cytotoxicity activity on breast cancer cells. The zeta potential value of the product was higher indicating good physical stability and dispersion quality of the SLNs. Cell proliferation assay revealed that the normal cell death rate was lower with Mn(II) SLNs which indicated lesser toxicity of the product to the normal cell. Moreover, higher early apoptosis rate was observed with Mn(II) complex SLN as compared to Mn(II) alone [54].
