**1.4 Transferesome**

Transferosomes are complex vesicular aggregate optimized to attain extremely flexible and self-regulating membrane; this makes the vesicles very deformable. Transferosome have the property to cross microporous barrier very efficiently, even when available passage are much smaller than the average aggregate size. Transferosome consists of natural amphipathic compound suspended in waterbased solution, something containing biocompatible surfactant. Transferosome also have lipid bilayer that surrounds an aqueous core and contain at least one component that soften the membrane and make skin more flexible. This allows an easy and rapid change in shape of transferosome [17].
