**2. Difference between phytosome and liposome**

The fundamental difference between liposomes and Phytosomes is that in liposomes the active principle is dissolved in the medium contained in the cavity or in the layers of the membrane, whereas in the Phytosome it is an integral part of the membrane, being the molecules anchored through chemical bonds to the polar head of the phospholipid [20].

There may be hundreds or even thousands of phosphatidylcholine molecules surrounding the water soluble compound in Liposome. In contrast, the Phytosome contain Phosphatidylcholine and the individual plant components actually form a 1:1 or a 2:1 complex depending on the substance. This difference show that Phytosomes being much better absorbed than liposomes. Phytosomes are superior to liposomes in skin care products [27, 28] (**Figure 3**).

Phytosome (lower segment) liposome (upper segment).

**Figure 3.** *Difference between phytosome and liposome [29].*
