**1.5 Ethosomes**

Ethosomes are lipid vesicles containing high amount of ethanol. They have the efficiency to penetrate the skin and enhance compound delivery both to deep skin strata and systemically. Ethanol fluidizes both lipid bilayers of the stratum corneum and intercellular lipid. The soft malleable vesicles then penetrate the disorganized lipid bilayer. This system consists of phospholipid, ethanol and water [18].
