Meet the editors

Dr. Rajeev K. Tyagi completed his Master's degree in Biotechnology at Meerut University, India. He completed his doctorate (PhD) in Immunology/Parasitology/Infectiology with a special mention of "Tres Honorable" at the Biomedical Parasitology Unit, Institute Pasteur, Paris, France (2011) and developed a preclinical "humanized" mouse model(s) to study asexual blood and liver-stage infection of *Plasmodium falciparum.* Dr. Tyagi

worked at the University of South Florida, Augusta University, and Vanderbilt University Medical Center, USA, as a postdoctoral scientist and deployed human chimeric mice to study *P. falciparum* and understand the immunological pathways of colitis. He has been working to develop novel drug delivery systems to deliver methotrexate and aceclofenac to explore their antiinflammatory effect in breast cancer, rheumatoid arthritis, etc. Dr. Tyagi has been employing his efforts to combine translational biomedical research with nanotechnology to develop therapeutic interventional approaches for inflammatory diseases and beyond. Currently, he has been working as a scientist at the CSIR-Institute of Microbial Technology (IM-TECH), Chandigarh, India.

Dr. Neeraj K. Garg is presently working as a formulation scientist (Manager) in Sun Pharmaceutical Industries Limited, Vadodara, India. His doctoral research focused on-to develop and optimize the novel lipid and polymer based nanocarriers for delivery of immunosuppressive drugs. Dr Neeraj have been working in the field of Advanced Drug Delivery System for last 15 years. He is working in the area of targeted lipid and polymeric nanoparti-

cles in general and development of Lipid and polymer based drug delivery vehicles; polymeric nanoparticles, solid lipid nanoparticles, lipid-polymer hybrid nanoparticles, nanostructure lipid carriers (NLCs), in particular.

Dr. Rahul Shukla is presently working as an assistant professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (Raebareli), India. He was awarded a PhD from JNU, New Delhi, a CSIR-CDRI and MPharm in Pharmaceutics from IIT-BHU, Varanasi, and a D.S. Kothari Post Doctoral Fellowship from Panjab University, Chandigarh. He had experience as a formulation scientist at Dr.

Reddy's laboratory, Hyderabad. He is presently guiding both doctoral students and master's students. He has published widely in areas of nanomedicine and targeted drug delivery systems, particle engineering, controlled release systems, neglected and tropical disease therapeutics, product development, and nutraceuticals in internationally renowned journals and books. He has delivered various lectures on many national and international platforms.

Professor P.S. Bisen, received PhD in 1972 and D.Sc. in 1981 from Jabalpur University, Jabalpur, India, guided 65 doctoral theses having 350 research publications and reviews to his credit in indexed international journals of repute with 12 international books (Springer, John Wiley, CRC Press and IntechOpen) on contemporary issues in Biological Sciences, served as Director of the Institute of Microbiology and Biotechnology, Barkatullah

Contents

**Preface III**

**Chapter 1 1** Aptamers for Targeted Delivery: Current Challenges and Future Opportunities

**Chapter 2 23**

**Chapter 3 59**

**Chapter 4 79**

**Chapter 5 95**

**Chapter 6 125**

**Chapter 7 139**

**Chapter 8 163**

Polymer Properties: Functionalization and Surface Modified Nanoparticles *by Chander Amgoth, Chiuyen Phan, Murali Banavoth, Santosh Rompivalasa* 

*by Bibhash Chandra Mohanta, Subas Chandra Dinda, Narahari Narayan Palei* 

Breaking down the Barrier: Topical Liposomes as Nanocarriers for Drug

Lipid Polymer Hybrid Nanoparticles: A Novel Approach for Drug Delivery *by Nayab Tahir, Muhammad Tahir Haseeb, Asadullah Madni, Farzana Parveen, Muhammad Muzamil Khan, Safiullah Khan, Nasrullah Jan and Arshad Khan*

Preparation and Characterisation of Niosomal Emulsions as Novel Drug

Solid Lipid Based Nano-particulate Formulations in Drug Targeting

Drug Delivery through Targeted Approach with Special References to

*by Arturo Santos, Juan C. Altamirano-Vallejo, José Navarro-Partida,* 

*by Chetan Chandola and Muniasamy Neerathilingam*

Delivery into the Posterior Segment of the Eyeball

*Alejandro González-De la Rosa and Jane H. Hsiao*

Delivery Vehicle Derived from Natural Seaweeds *by Reshma Joy, Franklin John and Jinu George*

*by Mahendra Rana, Aadesh Kumar and Amita J. Rana*

Applications of Chitosan in Pulmonary Drug Delivery

*by Xiuwen Guan and Weifen Zhang*

*and Jyotirmoy Deb*

Phytosomes

*and Guping Tang*

University, Bhopal, Vice-Chancellor, Jiwaji University, Gwalior, Direcor, Madhav Institute of Technology and Science, Gwalior, Director and Dean, JC Bose Institute of Life Sciences, Bundelkhand University, Jhansi and Principal Director and Advisor, Jaipur National University, Jaipur. He was a fellow of the UNESCO/UNDP/ ICRO and Hungarian Academy of Sciences at the Institute of Plant Physiology, Biological Research Center, Szeged, Hungary; U.S. National Science Foundation Fellow in the Department of Biological Sciences at the University of Illinois at Chicago and in the Department of Bacteriology at the University of California, Davis; UNESCO/ WHO fellow at the Institute of Microbiology, Czechoslovak Academy of Sciences, Budejovika, Praha, Czechoslovakia; European Commission's Marie Curie fellow at the Institute of Environmental and Biological Sciences, University of Lancaster, United Kingdom; and DAAD (German Academic Exchange Fellowship) fellow at the University of Bonn, Germany, awardees of First Indira Gandhi Fellowship for his outstanding work on environment conservation and management, National Overseas Associate ship of the Department of Biotechnology, Ministry of Science and Technology, Govt. of India, UGC Career Award, State Level Kailash Nath Katju Award of Government of Madhya Pradesh for contributions in Life Sciences. He was awarded the Life Time Professorship, the highest honor of Bundelkhand University, Jhansi, India. He has also worked as emeritus scientist (CSIR) at Defense Research Development Establishment, Defence Research Development Organization, Ministry of Defense, Government of India, Gwalior and is currently pursuing his research in the field of medical biotechnology as Advisor in the Institute of Medical Sciences, Jaipur National University, Jaipur with a research project on tuberculosis from Grand Challenges Canada, Govt. of Canada. Professor Bisen is the elected fellow of the National Academy of Sciences, India, for his enormous contributions to the field of biology. The diagnostic technology developed by Professor Bisen is unique in several respects and has received recognition worldwide. The technology has been patented in India, the United States, Europe, and Japan. He has served as the external scientific advisor to a Barcelona-based Spanish multinational company, Biokit, involved in the manufacturing of diagnostic kits and also serving as Scientific Adviser of an upcoming food industry, Tropilite Foods, based at Gwalior involved on probiotic research, food biotechnology and develops several innovative products for the food industry. Beijing Doing Institute of Translational Medicine Medical Group, China and Nan Yang Academy of Science Singapore appointed him as Senior Research Advisor.
