**3.1 Research on the self-healing capacity of human being should be enhanced**

The Luigi Cornaro diet clearly shows that our body has the self-healing capacity, with UA/SUA as its main component. We searched the term "self-healing" in Web of Science from 1990 to 2018, and 10,488 publications can be found. The Web of Science subject category analysis shows that most of the top 25 subject categories are in materials science and computer science, as shown in **Figure 5**. Only one subject category, dermatology, in the top 25 subject categories is related to medical science. Keyword analysis was carried out for these publications using VOSViewer, and 27,337 keywords are identified. Among these keywords, 2540 keywords have occurrences of five times and above, as shown in **Figure 6**. Using the clustering of keywords in the VOSViewer mapping in **Figure 6**, 11 topics are identified. **Table 1** gives the representative keywords in these 11 topics. It is very clear that, most of the keywords are on materials science and artificial intelligence of computer science. Furthermore, topic analysis on the keywords shows that the relative volume of self-healing research in medical science is shrinking in the last 29 years, from around 40% of the total publication in 1990 on self-healing to less than 10% in 2018, as shown in **Figure 7**. This is quite unusual, as "self-healing" is initially a medical term borrowed by materials science and computer science. So we suggest that the medical community should pay more attention to this self-healing capacity of the organs in our body, which can greatly lower the medical burden of every country in the world, and make our society more healthy.


### **Figure 5.**

*Top 25 Web of Science subject categories for publication on "self-healing" during 1990–2018.*

*Scientometrics Recent Advances*

Someren in 1901 [34]: "Did he (Luigi Cornaro) make use of a physiological process unknown to us, of the value of which he was not cognisant?" This also explain why

the Luigi Cornaro diet cannot be adopted by ordinary people.

**120**

**Figure 4.**

**Figure 3.**

*Research areas of publications used to interpret Luigi Cornaro diet.*

*The close relations among infection, autophagy and obesity.*
