**5. Disclaimer**

*Scientometrics Recent Advances*

preventing it from atrophy, avoiding its proneness for bacterial translocation and sepsis [13]. **Figure 8** shows the keywords mapping of publications on TPN, with the term "sepsis" highlighted. We can clearly see the close relation of TPN to sepsis. Based on the above discussion, we suggest that great caution should be placed on the use of TPN in treating sickness. TPN should only be conducted for seriously ill patients who are too emaciated to have proper running of SUA activity in their

*Keywords analysis for publications on TPN shows the close relation of TPN to bacterial translocation and sepsis.*

Specialization is an established part of the medical landscape nowadays, and the importance of specialization in medical research and practice should not be disdained. Yet, specialists are more or less focused on their own specialties, and isolated from other specialties. Here we use the rediscovery of the Luigi Cornaro diet as an example to show that, scientometrics can be a powerful tool in integrating various isolated medical specialties. After its publication in 1558, the simple diet of Luigi Cornaro, "Eat but Little," puzzled people for over 460 years. By analyzing the keywords in the titles and abstracts of publications on topics related to the Luigi Cornaro diet, we find that the fully developed sustained upregulated autophagy (SUA) without anorexia is a pre-requisite for the Luigi Cornaro diet. The fully developed SUA performed a multifaceted role in helping Luigi Cornaro maintaining the energy and nutrition balance; and effectively defending the common diseases like infection and the degeneration of body cells. This was why he could keep health until the end of his days, and his strength and senses were not affected while he was aging. Considering the connections among infection, illness-induced anorexia, upregulated autophagy (UA) and obesity, and sustained upregulated autophagy (SUA) and the Luigi Cornaro diet uncovered by scientometric analysis coupled with a long history of anecdotal evidence, a carefully designed study should be undertaken to confirm the causal link and define the conditions under which a Cornaro

body, and enteral feeding is truly not possible.

**4. Summary**

**Figure 8.**

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diet should be medically advised.

This chapter is based on the authors' limited personal experience and literature Surveys. The authors are not medical doctors and do not want to make medical recommendations. Instead, this chapter should be regarded as a thought-provoking impulse for future research. Neither the authors, the publisher, nor any other party who has been involved in the preparation or publication of this chapter guarantees that the information contained herein is in every respect accurate or complete. Therefore, this chapter is intended as reference only, and does not serve as a medical advice. The information in this publication is only to help you make informed decisions about your health. It is not intended as a substitute for any treatment that may have been prescribed by your doctor, who is familiar with your specific needs. If you suspect that you have a medical problem, we urge you to seek competent medical care.
