Meet the editor

Robert Reynolds is a Consulting Research Scientist for Mortality Research & Consulting, Inc., and a Visiting Data Scientist for the Human Health and Performance Directorate (HHPD) at NASA Johnson Space Center, through the Translational Research Institute for Space Health (TRISH) at the Baylor College of Medicine in Houston. Dr. Reynolds has a background in epidemiology and biostatistics, and is a Professionally Accredited Statistician® by

the American Statistical Association. He has published extensively on the mortality of space explorers, including US astronauts, Soviet and Russian cosmonauts, and International Partner astronauts. He is a self-trained health data scientist interested in how advanced analytics and machine learning can be employed to support operational decision making for human health and performance in spaceflight.

Contents

**Section 1**

**Section 2**

of Space Exploration

*by Robert J. Reynolds and Mark Shelhamer*

Effects of Microgravity on Human Physiology

Oral Tissue Responses to Travel in Space *by Maija I. Mednieks and Arthur R. Hand*

Spaceflight-Associated Immune System Modifications

*Stéphanie Ghislin, Sandra Kaminski and Jean-Pol Frippiat*

Space Radiation-Induced Hematopoietic Stem Cell Injury

*by Huihong Zeng, Mengzhen Yue and Lijian Shao*

**Preface III**

Introduction **1**

**Chapter 1 3**

Changes in Physiology Due to Spaceflight **11**

**Chapter 2 13**

**Chapter 3 35**

**Chapter 4 53**

**Chapter 5 79**

*by Satoshi Iwase, Naoki Nishimura, Kunihiko Tanaka and Tadaaki Mano*

*by Jeremy Jeandel, Coralie Fonte, Gaetano Calcagno, Julie Bonnefoy,* 

Introductory Chapter: Research Methods for the Next 60 Years
