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## Meet the editor

Assistant professor Selcan Karakuş is currently working in the Department of Chemistry, Istanbul University-Cerrahpasa (IUC), Turkey. She received her Master of Science degree in Physical Chemistry from Istanbul University (IU) in 2006 and her Doctor of Philosophy degree in Physical Chemistry from IU in 2011. She has worked as a visiting researcher at the University of Massachusetts, Department of Polymer Science and Engineer-

ing and has research experience in drug carrier systems, nanoparticles, nanocomposites, nanoemulsions, self-assembled polymeric nanostructures, and copolymer blends. She has worked on different projects funded by IUC, and has published several research articles and a book chapter on the above fields.

Contents

**Section 1**

Nanoparticles

Systems

**Section 2**

Delivery

*and Ikram Ullah Khan*

*and Ayben Kilislioglu*

*and Rohan Weerasooriya*

*by Camillo La Mesa and Gianfranco Risuleo*

*by Sunil Kumar, Pooja Dalal and Rekha Rao*

Self-Microemulsifying System *by Mansi Shah and Anuj G. Agrawal*

**Preface III**

Colloid Science and Nanoparticles **1**

**Chapter 1 3** The Viscosity Behaviour of PEGylated Locust Bean Gum/Rosin Ester Polymeric

**Chapter 2 17** Magnetic and Quantum Dot Nanoparticles for Drug Delivery and Diagnostic

**Chapter 3 33**

Colloid Science and Biotechnology **45**

**Chapter 4 47**

**Chapter 5 59**

**Chapter 6 79**

**Chapter 7 103**

Colloid Stability Influences on the Biological Organization and Functions

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug

Effect of Cyclodextrin Derivatization on Solubility and Efficacy of Drugs *by Syed Haroon Khalid, Mehreen Bashir, Sajid Asghar, Tauqeer Hussain Mallhi* 

*by Selcan Karakus, Merve Ilgar, Ezgi Tan, Yeşim Müge Sahin, Nevin Tasaltin* 

*by Erandi Munasinghe, Maheshi Aththapaththu and Lakmal Jayarathne*

Adsorption Configurations of 2-Chlorophenols on Colloidal Silica *by Lakmal Jayarathna, Nelum Karunathilake, Athula Bandara* 

### Contents


*by Syed Haroon Khalid, Mehreen Bashir, Sajid Asghar, Tauqeer Hussain Mallhi* 

*and Ikram Ullah Khan*

Preface

uniformly dispersed in a solution. In colloidal dispersions, there are two phase systems: continuous phase and dispersed phase (ranging from 1 nm to 1 µm). The colloidal particle/nanoparticle is produced by considering various key factors such as particle size, distribution, polarity, and surface properties. The stability of colloidal dispersion has a role in homogeneous distribution with steric and electrostatic modifications.

The definition of a colloidal particle is a micro/nanometer-sized solid particle

Recently, colloidal and nanotechnological approaches have been considered as advanced technologies. Nanotechnology is known as scientific and engineering knowledge that makes it possible to use nanosized materials in special applications. Nanotechnology has developed science and technology by producing superior products and it has a multidisciplinary approach. Nanotechnological products have attracted much attention with many new studies concentrating on colloids and nanoparticles in biotechnology for biomedical and environmental applications. Materials science, engineering, medicine, dentistry, drug delivery, etc. have all used this approach. Knowledge of nanoscience and nanoengineering is being used to produce nanotechnology-based products such as nanoparticles, nanolayers, nanocomposites, nanofibers, oil-in-water nanoemulsions, cyclodextrin-nanosponges, etc. Colloidal particles/ nanoparticles are preferred because of their biocompatibility and performance in pharmaceutical applications. For this purpose, colloidal particles are also widely used in the development of novel drug delivery systems for use in diagnosis and treatment.

*Colloid Science in Pharmaceutical Nanotechnology* is comprised of seven chapters that provide an overview of colloidal particle and nanoparticle systems, their physicochemical properties, and pharmaceutical applications. Some of the topics covered are nanoparticle-based drug design, the miscibility of colloidal particles, and the stability of nanoparticles. The preparation and characterization of colloidal systems are discussed in detail. In this book, the authors focus on recent studies, applications, and new technological developments of the fundamental properties of colloidal particle systems. Readers will be able to access recent studies, applications, and new technological developments on colloidal systems. We sincerely thank our authors who have contributed with experience and knowledge to this book. Especially, our thanks go to Erbil Karakuş, Emir Ersel Karakuş and the editorial

> **Selcan Karakuş** Assistant Professor, Department of Chemistry, Faculty of Engineering, Istanbul, Turkey

> > University-Cerrahpasa, Istanbul, Turkey

team from IntechOpen for their assistance in preparing this book.
