**5. Conclusions**

Synthesizing GNS by seeding and growing a gold shell over silica spheres with GNPs showed to be an effective method to tune their absorption to the NIR. The SEM and TEM images show the evolution of the process, while the absorbance spectrum displays the GNS shifting over the NIR. Therefore, we obtained a simple technique of producing GNS that can be used for medical applications thanks to the bio-inert GNPs [3] and the widely studied cytotoxicity of the silica [5]. This method does not require long periods of time, when compared with previously published mechanisms, and does not need sophisticated equipment.

### **Acknowledgements**

We thank Consejo Nacional de Ciencia y Tecnologia (Conacyt) and Centro de Investigacion en Materiales Avanzados (CIMAV) for the financial support, Dr. Jose Guadalupe Murillo Ramirez for his help with the use of 852 nm wavelength laser, Dr. Pedro Piza for lending us the thermographic camera, Ing. Wilber Antunez Flores, and M.C. Karla Campos Venegas for helping us obtain the TEM and SEM images.

**101**

**Author details**

Rosa Isela Ruvalcaba Ontiveros1

Anel Rocío Carrasco Hernandez1

Juan Manuel Olivares Ramírez<sup>2</sup>

Erasmo Orrantia Borunda1

provided the original work is properly cited.

*A Simple Way to Produce Gold Nanoshells for Cancer Therapy*

*DOI: http://dx.doi.org/10.5772/intechopen.82495*

SPR surface plasmon resonance

APTES 3-aminopropyltriethoxysilane

TEM transmission electron microscope SEM scanning electron microscope TEOS tetraethyl orthosilicate

GNSs gold nanoshells

NIR near-infrared

GNP gold nanoparticles

**Nomenclature**

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

, José Alberto Duarte Moller1

, Cynthia Deisy Gómez Esparza1

1 Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, México

2 Universidad Tecnológica de San Juan del Río, San Juan del Río, México

\*Address all correspondence to: alberto.duarte@cimav.edu.mx

, Hilda Esperanza Esparza-Ponce1

\*,

and

,

*A Simple Way to Produce Gold Nanoshells for Cancer Therapy DOI: http://dx.doi.org/10.5772/intechopen.82495*
