**2.2 The site-specific transcription factors**

Transcription mediator interplays with the transcription activator proteins and the GTFs to enable plasticity and flexibility of gene expression [7]. However, site-specific TF-mediated and TATA-independent transcription system should be investigated because it may control responses to stresses. The TFs are categorized by their amino acid sequences or domain structures according to TRANSFAC (www. edgar-wingender.de/huTF\_classification.html) database [8]. Some proteins might have multiple characteristic motifs.
