**Acknowledgements**

This work is supported by National Natural Science Foundation of China (Nos. 81671707, 81571701, and 81530056), Natural Science Foundation of Guangdong Province (Nos. 2017A030313651 and 2016A030311054), Research Projects of Guangzhou Science Technology and Innovation Commission (No. 201607010201), and Research Fund for Lin He's Academician Workstation of New Medicine and Clinical Translation.
