**5.2 Progressive supranuclear palsy**

Progressive supranuclear palsy (PSP) is a condition associated with Parkinsonism and dementia. Pathological changes are most common in the basal ganglia and brain stem, and features of this neurodegenerative condition include behavioral derangement and cognitive decline (Ishii, 2002). In FDG PET of PSP patients, glucose metabolism is reduced in the lateral and medial frontal lobes, caudate nucleus and midbrain, when compared to normal controls (Blin, et al., 1990; Hosaka, et al., 2002).
