**2. Future of these gene-silencing technologies**

While the RNAi technique ruled the tailoring of eukaryotic gene expression in the last two decades, the CRISPR/Cas9 system is fairly pretty recent and therefore requires much more exploration and optimization. The superiority of the CRISPR/Cas9 system in effectiveness and efficiency, along with its vast popularity among research community certainly raises the question if in coming years the RNAi technology is going to be obsolete. Application wise, the CRISPR/Cas9 technology truly has the potential to outweigh the RNAi technology, but there is a long road ahead before we can freely make permanent edits to human DNA.-
