**1.2. Abridging the two prominent gene-silencing technologies**

Although mechanistically different, the two techniques may complement one another very well.- Genes can be knocked down with RNA interference (RNAi) or knocked out with CRISPR-Cas9;- when used together, they facilitate the discovery and validation of scientific findings. Researchers- can do a whole genome RNAi library screen now by using synthetic siRNAs, and then validate- each target by designing specific sgRNAs and utilizing the CRISPR-Cas9 technology.-
