Contents

#### **Preface XI**


Chapter 5 **A Study of the Correlation between Bacterial Culture and Histological Examination in Children with Helicobacter pylori Gastritis 79** Felicia Galoș, Gabriela Năstase, Cătălin Boboc, Cristina Coldea,

Mălina Anghel, Anca Orzan and Mihaela Bălgrădean

Chapter 6 **Bone Marrow Mesenchymal Cell Contribution in Maintenance of Periodontal Ligament Homeostasis 93** Toshiyuki Kawakami, Keiko Kaneko, Tatsuo Takaya, Saeka Aoki, Rina Muraoka, Mihoko Tomida, Norimasa Okafuji, Masahito Shoumura, Naoto Osuga, Keisuke Nakano, Hidetsugu Tsujigiwa and Hitoshi Nagatuka


Preface

would benefit from further exploration.

plines as fascinating as many generations before them.

microtomy, section acquisition, and staining.

Histology is the science of tissues and as such histology studies cells and tissues of organs using a variety of techniques. Histology goes back more than 200 years when the French surgeon Bichat used the term "tissues," followed by the introduction of the term "histology" by Karl Meyer in the early nineteenth century. Among the early histologists were Camillo Golgi and Santiago Ramon y Cajal who presented the wonders of cellular building blocks to the world and started to elaborate the structure of cell and tissue specimens, specifically nerve cells. From their time to today's most sophisticated analysis of cell structure and func‐ tion, microscopes and imaging techniques have undergone an exciting evolution that allows us to understand microscopic details and cellular function at the molecular level. Histologi‐ cal techniques are used in different disciplines: research, teaching, and clinical applications. This book explores the research currently being carried out at the molecular, subcellular, and cellular levels, both in normal and pathological processes, from genetic mechanisms to intra- and intercellular signaling. This book includes cutting-edge research reviews and de‐ scriptions of technological advances to modify bodily cells and tissues. Targeted at students and researchers in biological, medical, and related disciplines, this book will provide an overview of the work being done in this field, and will highlight any gaps and areas that

The book contains eight chapters in four sections and presents reviews in different areas of histology written by experts in their respective fields. Basic histology, cell biology, histopa‐ thology, and histological techniques are featured prominently as a recurring theme through‐ out several chapters. This book will be a most valuable resource for histologists, cell biologists, pathologists, and other scientists alike. In addition, it will contribute to the train‐ ing of current and future biomedical scientists who find histology and its associated disci‐

Chapter 1 introduces the topic of this book by discussing histological processing and prepa‐ ration of tissues. Thereby, the chapter familiarizes the reader with histological microtechni‐ ques, including tissue acquisition, fixation, dehydration, clearing, infiltration, embedding,

In Chapter 2, authors discuss the histological, cellular, and molecular mechanisms that gov‐ ern early epithelium development in the thymus. The authors emphasize the resemblance of the thymus with the process of branching morphogenesis and tubulogenesis that occurs in other epithelial organs such as those derived from the gut such as the mammary gland, sali‐ vary glands, lungs, kidneys, and pancreas. These organs repeatedly fold to reach an enlarged area, which is necessary to perform their major functions, namely, gas exchange, excretion,
